【摘要】 脓毒症是由感染引起的全身炎性反应失调导致的危及生命的器官功能障碍，脂肪组织作为脓毒症患者短期与长期生存的保护性因素，参与调节炎性反应相关生物活性物质的产生和释放，其中包括大量可溶性脂肪因子，如脂联素、鸢尾素、瘦素、抵抗素等，其可通过调控内皮细胞活化与黏附分子表达、保护线粒体功能及调节细胞免疫和体液免疫等不同作用机制对脓毒症患者的预后产生影响。本文就脂肪组织及脂肪因子在脓毒症中作用及机制的研究进展作一综述。更多还原

【Abstract】 Sepsis is a life-threatening organ dysfunction caused by a dysregulated systemic inflammatory response to infection. Adipose tissue, as a protective factor for both short-and long-term survival in septic patients, participates in coordinating the production and release of inflammatory response-associated bioactive substances, including a large number of soluble adipokines such as adiponectin, irisin, leptin and resistin. These adipokines can influence the prognosis of sepsis patients through different mechanisms of action, such as modulating endothelial cell activation and adhesion molecule expression, protecting mitochondrial function, and regulating cellular immunity and humoral immunity. This paper reviews the research progress of the roles and mechanisms of adipose tissue and adipokines in sepsis.更多还原