【摘要】 目的：对夏桑菊核桃灸的灸粉进行剂型改良，将其改制为夏桑菊核桃灸凝胶眼贴，确定最佳制备工艺。方法：在物料用量考察单因素实验基础上，以综合感官、初黏力和持黏力为评价指标，采用L₉（3⁴）正交试验法优化聚丙烯酸钠（NP-700）、羧甲基纤维素钠（CMC-Na）、甘羟铝、酒石酸的用量。结果：优选出最佳物料处方为夏桑菊药粉1.500 g、NP-700 0.400 g、CMC-Na 0.400 g、甘羟铝0.015 g、甘油5.000 g、蒸馏水4.000 g、酒石酸0.020 g，最佳搅拌时间为30 min，最佳搅拌温度为20～40℃。结论：该制备工艺简便稳定可行，所制备的夏桑菊核桃灸凝胶眼贴性能良好，适合制剂开发生产。更多还原

【Abstract】 Objective: To reform the dosage form of Xiasangju walnut moxibustion powder, change it into Xiasangju walnut moxibustion eye-cataplasm, and determine the best preparation process. Methods: Based on the single factor experiment of material usage inspection, the amount of sodium polyacrylate（NP-700）, sodium carboxymethyl cellulose（CMC-Na）, aluminum glycyrrhizinate and tartaric acid are optimized by L₉（3⁴） orthogonal experiment with comprehensive sensory, initial viscosity and viscosity as evaluation indexes. Results: The best prescription is Xiasangju medicine powder 1.500 g, NP-700 0.400 g, CMC-Na 0.400 g, aluminum glycyrrhizinate0.015 g, glycerin 5.000 g, distilled water 4.000 g, and tartaric acid 0.020 g. The best stirring time is 30 min,and the best stirring temperature is 20～40 ℃. Conclusion: The preparation process is simple, stable and feasible.The prepared Xiasangju walnut moxibustion eye-cataplasm has good performance and it is suitable for the development and production of preparations.更多还原