【摘要】 【目的】探讨苯乙酰谷氨酰胺(PAGln)、苯乙酰甘氨酸(PAGly)对动脉粥样硬化型急性脑梗死(ACI)患者预后的评估价值。【方法】检测60例动脉粥样硬化型ACI患者的PAGln、PAGly表达水平，根据90 d的随访情况将患者分为预后良好组和预后不良组。比较两组患者临床相关资料及PAGln、PAGly水平，分析影响ACI患者预后的相关因素，并评估PAGln、PAGly对ACI患者预后的预测价值。【结果】60例患者中，预后良好组41例，占68.33%(41/60),预后不良组19例，占31.67%(19/60)。Logistic分析显示，美国国立卫生研究院卒中量表(NIHSS)评分、血小板活性及血清PAGln、PAGly水平偏高、颈动脉斑块不稳定均为ACI患者预后不良的危险因素(P<0.05)。受试者工作特征(ROC)曲线分析显示，PAGln、PAGly单一及联合检测预测ACI患者预后的曲线下面积(AUC)分别为0.795、0.780、0.964,且两者联合预测效能高于单一预测效能(P<0.05)。【结论】PAGln、PAGly表达水平可用于评估ACI患者的预后。更多还原

【Abstract】 【Objective】 To investigate the prognostic evaluation value of phenylacetylglutamine(PAGln) and phenylacetylglycine(PAGly) in patients with atherosclerotic acute cerebral infarction(ACI).【Methods】 The expression levels of PAGln and PAGly were measured in 60 patients with atherosclerotic ACI. Based on the 90-day follow-up outcomes, patients were divided into a good prognosis group and a poor prognosis group. Clinical data and levels of PAGln and PAGly were compared between the two groups. Logistic regression analysis was used to identify factors influencing ACI prognosis, and assess the predictive value of PAGln and PAGly for patient outcomes.【Results】 Among the 60 patients, 41(68.33%) cases had a good prognosis and 19(31.67%) cases had a poor prognosis. Logistic regression analysis showed that higher National Institutes of Health Stroke Scale(NIHSS) scores, carotid plaque instability, platelet activity, and elevated serum PAGln and PAGly levels were independent risk factors for poor prognosis in ACI patients(P<0.05). Receiver operating characteristic(ROC) curve analysis revealed that the areas under the curve(AUC) for PAGln and PAGly alone in predicting prognosis were 0.795 and 0.780, respectively, and that their combined detection had higher predictive efficiency than either marker alone(P<0.05).【Conclusion】 Plasma PAGln and PAGly levels can be used as biomarkers to evaluate the prognosis of patients with atherosclerotic acute cerebral infarction.更多还原