【摘要】 目的 观察药物包被球囊(DCB)对早发冠心病(PCAD)患者生活质量的影响。方法 连续纳入2017年1月至2020年1月于郑州大学第一附属医院心内科成功行冠脉介入治疗的早发冠心病患者295例,根据治疗策略分为DCB组(154例)和药物洗脱支架(DES)组(141例),术前应用简明健康状况调查表(SF-36)和抑郁自评量表(SDS)评估PCAD患者生活质量,同时记录临床和手术基线资料。经过中位数为41个月的临床随访,记录两组的主要不良心血管事件(包括靶病变血运重建、心肌梗死等);术后12个月通过门诊或电话随访评估患者生活质量。结果 两组靶病变血运重建及主要不良心血管事件累积发生率差异无统计学意义(P > 0.05)。DCB组术后SF-36评分均较术前提高(P<0.001),而SDS评分较术前下降(P<0.001)。DES组术后12个月SF-36评分除了心理健康、情感角色这2个维度评分较术前有所下降外,其余维度评分较术前均提高(P<0.001),SDS评分较术前升高(P<0.001)。DCB组介入治疗前后大部分SF-36条目及SDS量表改善情况高于DES组(P<0.05)。结论 在接受介入治疗的PCAD患者中,DCB治疗可改善早发冠心病患者生活质量,且其改善较DES治疗更为显著。更多还原

【Abstract】 Objective To observe the effect of drug-coated balloon(DCB) on the quality of life of patients with premature coronary artery disease(PCAD). Methods A total of 295 patients with premature coronary heart disease who successfully underwent coronary intervention in the Department of Cardiology of the First Affiliated Hospital of Zhengzhou University from January 2017 to January 2020 were included in the study. They were divided into DCB group(154 cases) and drug-eluting stent(DES) group(141 cases) according to the treatment strategy. The quality of life of patients with PCAD was evaluated with 36-item short form survey(SF-36) and self rating depression scale(SDS) before surgery,and the clinical and surgical baseline data were recorded. After a median of 41 months of clinical follow up,the main adverse cardiovascular events(including target lesion revascularization,myocardial infarction,etc.) in the two groups were recorded. The patients’ quality of life was evaluated by outpatient or telephone follow-up 12 months after operation. Results There was no significant difference in the target lesion revascularization and the cumulative incidence of major adverse cardiovascular events between the two groups(P >0. 05). In DCB group,the score of SF-36 after operation was higher than that before operation(P < 0. 001),while the score of SDS was lower than that before operation(P < 0. 001). In DES group,the scores of SF-36 in 12 months after surgery were higher than those before surgery(P < 0. 001),except for the scores of mental health and emotional role,which were lower than those before surgery,and the scores of other dimensions were higher than those before surgery(P < 0. 001),while the scores of SDS were higher than those before surgery(P < 0. 001). The improvement of most SF-36 items and SDS scale in DCB group before and after interventional therapy was higher than that in DES group(P < 0. 05). Conclusion DCB therapy can improve the quality of life of patients with premature coronary heart disease in patients with PCAD receiving interventional therapy,and the improvement is more significant than that of DES therapy.更多还原