【摘要】 牙周炎作为一种慢性感染性疾病，主要由牙菌斑中的细菌侵犯牙周组织所致，其特征表现为牙周支持组织的进行性破坏，最终导致牙齿松动、移位甚至丧失，对口腔健康以及全身健康产生巨大影响。铁死亡是一种由脂质过氧化驱动、由核受体共激活因子4促进的调节性细胞死亡方式，其主要特征包括细胞内铁超载、活性氧激增、谷胱甘肽耗竭以及脂质过氧化等。而这些特征不仅是铁死亡发生的直接原因，还与牙周炎有着密切联系。铁超载、大量ROS堆积、脂质过氧化等过程在牙周炎患者中同样可以被观察到。本文将围绕铁死亡与牙周炎及其之间关系的研究进展进行综述，为牙周炎的发病机制以及临床治疗提供新的理论依据。更多还原

【Abstract】 As a chronic infectious disease, periodontitis was mainly caused by bacteria in dental plaque invading periodontal tissue. It was characterized by progressive destruction of periodontal supporting tissue, and eventually leads to loosening, displacement or even loss of teeth, which has a great impact on oral health and general health. Ferroptosis was a mode of regulatory cell death driven by lipid peroxidation and facilitated by nuclear receptor coactivator 4.Its main characteristics included intracellular iron overload, reactive oxygen species surge, glutathione depletion, and lipid peroxidation. These characteristics were not only the direct cause of iron death, but also closely related to periodontitis. Iron overload, a large amount of reactive oxygen species accumulation, lipid peroxidation and other processes can also be observed in periodontitis patients. This article will review the research progress of iron death and periodontitis and their relationship, and provide a new theoretic foundation for the nosogenesis and clinical treatment of periodontitis.更多还原