【摘要】 目的 探讨氨磺必利对精神分裂症患者心电图的影响及相关风险因素的多元变量分析。方法 筛选381例服用氨磺必利患者的心电图及临床资料，对主要诊断、心率、QTc间期及相关风险因素进行统计分析，计数资料采用χ~2检验，计量资料采用方差分析。结果 服药8周时心电图异常率为33.1%，其中心动过缓发生率为12.1%,QTc间期延长发生率为3.9%。服药各观察点的心率均较服药前减缓(P<0.05)，服药6周时中年组心率慢于青年组(P<0.05)。男性QTc间期较女性短，青年组QTc间期较中年组短，服药8周的QTc间期较服药前延长(P<0.05);青年组女性服药各观察点的QTc间期均较男性延长(P<0.05)，男性患者中年组服药2、4、6周的QTc间期较青年组延长(P<0.05)，青年男性服药6、8周的QTc间期较服药前延长(P<0.05)。结论 服用氨磺必利有减慢心率及延长QTc间期的风险，临床用药时应密切监测心电图变化，尤其应增加女性、高龄以及服药6周以上患者的监测频率。更多还原

【Abstract】 Objective To investigate the effect of amisulpride on electrocardiographic changes in patients with schizophrenia and the multivariate analysis of associated risk factors. Methods The electrocardiographic and clinical data of 381 patients who were taking amisulpride were screened. Statistical analyses were performed on the main diagnoses,heart rate,QTc interval,and related risk factors by the χ~2 test for counting data and ANOVA for measuring data. Results At the 8th week of drug intake,the rate of electrocardiographic abnormality was 33. 1%,of which the incidence of bradycardia was 12. 1% and the incidence of QTc interval prolongation was 3. 9%. The heart rate at all observation points after taking the drug was slower than pre-dose(P <0. 05),and the heart rate of the middle-aged group was slower than that of the young group at the 6th week of taking the drug(P < 0. 05). The QTc interval was shorter in males than in females,and the QTc interval was shorter in the young group than in the middle-aged group,and the QTc interval at week 8 of drug administration was prolonged compared with the pre-drug period(P < 0. 05). In the young group,females had longer QTc intervals compared to males after drug administration(P < 0. 05). In male patients,the QTc intervals were prolonged in the middle-aged group at weeks 2,4 and 6 of drug administration compared with the young group(P < 0. 05). The QTc intervals at weeks 6 and 8 of drug administration were prolonged in young men compared to pre-drug administration(P < 0. 05). Conclusion The administration of amisulpride carries a risk of slowing the heart rate and prolonging the QTc interval. Therefore,electrocardiographic changes should be closely monitored during clinical use,particularly in women,elderly patients,and patients who have been taking the drug for more than 6 weeks should be monitored more frequently.更多还原