【摘要】 目的 评价绞股蓝复方减肥茶对食源性肥胖大鼠的减肥作用，为药食同源的中药材类减肥保健品的开发提供理论依据。方法 采用高热量模型饲料制备食源性肥胖大鼠模型，设对照组、模型组和绞股蓝复方减肥茶低、中、高3个剂量组（0.83、1.67、5.01 g/kg，分别相当于人体推荐量的5倍、10倍、30倍）。模型对照组和3个剂量组给予高热量模型饲料，空白对照组给予维持饲料。各剂量组按10 m L/kg剂量灌胃给予不同剂量的受试样品，模型对照组和空白对照组给予等量的相应溶剂。每周记录体重、摄食量变化。干预6周后，称空腹体重，解剖取肾周围脂肪、睾丸周围脂肪，并称重，计算脂体比。结果 绞股蓝复方减肥茶中、高剂量组大鼠实验期体重增重分别为（145.8±29.4）、（144.4±38.1）g，低于模型对照组（187.6±34.0）g；睾丸及肾周围脂肪重量分别为（19.65±5.23）、（17.09±5.03）g，低于模型对照组（24.32±7.13）g；高剂量组大鼠脂体比为（3.59±0.84）%，低于模型对照组（4.79±1.12）%，以上差异均有统计学意义（P均<0.05）。不同组别大鼠摄食量、食物利用率和摄入热量比较，差异均无统计学意义（F=1.236、2.728、1.236,P均>0.05）。结论 绞股蓝复方减肥茶对食源性肥胖大鼠具有减肥作用。更多还原

【Abstract】 Objective To evaluate the weight-loss effect of Gynostemma pentaphyllum compound slimming tea on the rats with,diet-induced obesity so as to provide theoretical evidence for the development of weight-loss health products made from food-medicine homologous traditional Chinese medicinal materials. Methods A high-calorie model diet was used to prepare a diet-induced obese rat model. The rates were divided into a blank control group, a model control group, and three dosage groups of low, medium, and high doses of Gynostemma pentaphyllum compound slimming tea(0.83, 1.67 and 5.01 g/kg, respectively, corresponding to 5 times, 10 times, and 30 times the recommended human dose, respectively). The model control group and the three dose groups were fed a high-calorie model diet, while the blank control group was fed a maintenance diet. The rates in the three dosage groups were administered with different doses of test samples by oral gavage at a dose of 10 m L/kg, while the model control group and blank control group received equal amounts of corresponding solvents. Changes in body weight and food consumption were recorded weekly. After 6 weeks of intervention, fasting body weight was measured, and the perirenal fat and peritesticular fat collected after dissection were weighed to calculate the fat-to-body weight ratio. Results The body weight gains in the medium and high dose groups of Gynostemma pentaphyllum slimming tea during the experimental period were(145.8 ±29.4) and(144.4±38.1) g, respectively, which were both lower than those in the model control group(187.6±34.0) g; the weights of testicular and perirenal fat were(19.65±5.23) and(17.09±5.03) g, respectively, which were both lower than those in the model control group(24.32±7.13) g; the fat-to-body weight ratio in the high-dose group was(3.59±0.84)%, which was lower than that in the model control group(4.79±1.12)%. The differences mentioned above were statistically significant(all P<0.05). There were no statistically significant differences in food intake, food utilization efficiency and caloric intake among the groups(F=1.236, 2.728 and 1.236, respectively, and all P>0.05). Conclusions Gynostemma pentaphyllum compound slimming tea has a weight loss effect on diet-induced obese rats.更多还原