【摘要】 血流储备分数(fractional flow reserve,FFR)作为冠状动脉疾病功能学评估的成熟手段，近年来已逐步应用于下肢动脉疾病的诊疗实践，旨在通过功能学指标提高血运重建的精准度。FFR能够量化狭窄病变对血流动力学的实际影响，有效弥补了传统影像学检查在判断病变功能意义方面的局限。该技术在下肢动脉疾病中的应用涵盖多个关键场景，包括非重度间歇性跛行患者的功能评估、血管准备后治疗策略的优化选择以及术后血流重建效果与并发症的预测。随着压力导丝、微导管系统及基于无创影像的FFR衍生技术的发展，FFR在临床中的可操作性与适用性不断提升。然而下肢动脉系统解剖结构复杂、病变常伴严重钙化与弥漫性特征，且目前尚缺乏统一的FFR临界值标准，仍是当前推广该技术所面临的主要挑战。推动FFR在下肢动脉疾病中的规范应用，对实现从解剖修复向功能重建的诊疗模式转型具有重要意义。更多还原

【Abstract】 Fractional flow reserve(FFR), an established modality for functionally assessing coronary artery disease, is increasingly applied to diagnose and manage lower extremity arterial disease. By incorporating functional parameters, FFR enhances revascularization precision by quantifying the hemodynamic impact of stenotic lesions, thereby overcoming limitations of conventional imaging. Key clinical applications in lower extremity disease include functional assessment in moderate intermittent claudication, post-vascular preparation strategy optimization, and predicting revascularization outcomes and complications. Advances in pressure wire and microcatheter systems, alongside non-invasive imagingderived FFR techniques, are improving its feasibility and applicability. However, widespread adoption is challenged by the complex anatomy of the lower extremity arterial system, frequent severe calcification and diffuse disease, and a current lack of standardized FFR cutoff values. Promoting the standardized use of FFR is crucial for shifting the clinical management paradigm from anatomy-based repair toward functional reconstruction.更多还原