【摘要】 目的 探究血清载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)水平与缺血性脑血管病（ICD）患者病情及预后的关系。方法 选取铜陵市人民医院2020-06—2024-03收治的112例ICD患者为试验组，另选取同期本院体检中心无动脉粥样硬化的体检者112例为对照组。对比2组患者血清ApoA1、ApoB水平，比较不同颈内动脉狭窄程度、不同预后ICD患者的血清ApoA1、ApoB水平，分析血清ApoA1、ApoB水平对患者预后的预测价值。结果 试验组ApoA1水平低于对照组，ApoB水平高于对照组（P<0.05）。轻度、中度、重度动脉狭窄程度的ICD患者ApoA1、ApoB水平比较差异有统计学意义（P<0.05），且重度动脉狭窄ICD患者ApoA1水平低于中度、轻度，ApoB水平高于中度、轻度，中度动脉狭窄ICD患者ApoA1水平低于轻度，ApoB水平高于轻度（P<0.05）。预后良好ICD患者ApoA1水平高于预后不良患者（P<0.05）,ApoB水平低于预后不良患者（P<0.05）。受试者工作特征（ROC）曲线显示，ApoA1、ApoB联合预测ICD患者预后的AUC最高，为0.900，敏感度86.08%，特异度87.88%。结论 ApoA1在ICD患者血清中表达降低，APOB表达升高。随着颈内动脉狭窄的加重，APOA1表达进一步降低，ApoB表达进一步升高，二者联合预测ICD患者预后具有良好的价值。更多还原

【Abstract】 Objective To investigate the relationship between serum apolipoprotein A1(ApoA1) and apolipoprotein B(ApoB) levels and the severity and prognosis of ischemic cerebrovascular disease(ICD).MethodsTotally 112 patients with ICD admitted to Tongling People’s Hospital from June 2020 to March 2024were selected as experimental group. Meanwhile, 112 individuals without atherosclerosis who received physical examination at Physical Examination Center of Tongling People’s Hospital were selected as control group. Serum ApoA1 and ApoB levels in the two groups were compared. Serum ApoA1 and ApoB levels in ICD patients with different degrees of internal carotid artery stenosis and different prognoses were comparatively analyzed. The prognostic value of serum ApoA1 and ApoB levels was evaluated.ResultsApoA1 level in the experimental group was lower than that in the control group, and ApoB level was higher than that in the control group(P<0.05). There were statistically significant differences in the levels of ApoA1 and ApoB among ICD patients with mild, moderate, and severe arterial stenosis(P<0.05). ApoA1 level in ICD patients with severe arterial stenosis was lower than those in patients with moderate and mild arterial stenosis,ApoB level was higher than those in patients with moderate and mild arterial stenosis. ApoA1 level in ICD patients with moderate arterial stenosis was lower than that in patients with mild arterial stenosis, and ApoB level was higher than that in patients with mild arterial stenosis(P<0.05). ApoA1 level in ICD patients with good prognosis was higher than that in patients with poor prognosis, and ApoB level was lower than that in patients with poor prognosis(P<0.05). The receiver operating characteristic(ROC)curves indicated that the AUC of ApoA1 combined with ApoB for predicting the prognosis of patients with ICD was the largest, which was 0.900. The sensitivity and specificity were 86.08% and87.88%, respectively.ConclusionApoA1 expression reduces and ApoB expression increases in the serum of patients with ICD. As internal carotid artery stenosis gets worse, ApoA1 expression decreases and ApoB expression increases. The combination of two is helpful for predicting the prognosis of patients with ICD.更多还原