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非传统血脂参数与颈动脉粥样硬化的研究进展

Research progress of non-traditional blood lipid parameters and carotid atherosclerosis

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【作者】 王俊娟; 张建斌; 黎飘; 刘超宇;

【Author】 WANG Junjuan;ZHANG Jianbin;LI Piao;LIU Chaoyu;Heping Hospital Affiliated to Changzhi Medical College;Heji Hospital Affiliated to Changzhi Medical College;

【通讯作者】 张建斌;

【机构】 长治医学院附属和平医院; 长治医学院附属和济医院;

【摘要】 动脉粥样硬化性疾病是全球关注的热门问题,最主要的原因是血脂异常。近些年,中国人群血脂异常患病率显著增加,以血清LDL-C水平为干预靶点的血脂管理取得了一定的疗效,但效果并不理想,期望更敏感的参数作为降脂靶点,以进一步降低心脑血管事件风险。越来越多的研究表明,非传统血脂参数,包括非高密度脂蛋白胆固醇和多种血脂比值,血脂比值包括non-HDL-C/HDL-C、TC/HDL-C、TG/HDL-C、LDL-C/HDL-C和ApoB/ApoAI等,同时包含致动脉粥样硬化和抗动脉粥样硬化颗粒信息,并且已被证明与颈动脉粥样硬化有关,但其在颈动脉粥样硬化中的作用尚不清楚。本文对非传统血脂参数与颈动脉粥样硬化的关系进行综述。

【Abstract】 Atherosclerotic disease is a hot issue of global concern,and the main reason is dyslipidemia. In recent years,the incidence of dyslipidemia in the Chinese population has significantly increased. Lipid management targeting serum LDL-C levels has achieved certain therapeutic effects,but the effect is not ideal. It is expected that more sensitive parameters will be used as lipid-lowering targets to further reduce the risk of cardiovascular and cerebrovascular events. More and more studies have shown that non-traditional lipid parameters,including non high-density lipoprotein cholesterol and multiple lipid ratios,lipid ratios,including non-HDL-C/HDL-C,TC/HDL-C,TG/HDL-C,LDL-C/HDL-C and ApoB/ApoAI,also contain information on atherogenic and anti-atherosclerotic particles,and have been proved to be related to carotid atherosclerosis,but its role in carotid atherosclerosis is still unclear. This article reviews the relationship between non-traditional lipid parameters and carotid atherosclerosis.

【基金】 山西省高校科技研究开发项目(编号:20121014)
  • 【文献出处】 中国实用神经疾病杂志 ,Chinese Journal of Practical Nervous Diseases , 编辑部邮箱 ,2025年05期
  • 【分类号】R743
  • 【下载频次】19
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