【摘要】 目的 评估帕金森病（PD）患者中伴阻塞性睡眠呼吸暂停（OSA）患者（PD+OSA）与未伴OSA患者（PD-OSA）的认知功能，同时观察持续气道正压（CPAP）治疗对PD+OSA患者认知功能的改善情况。方法 连续纳入2022-04—2024-04于郑州大学第五附属医院治疗的PD患者，通过夜间多导睡眠图筛选出PD+OSA患者与PD-OSA患者，通过简易智力状态检查量表（MMSE）和蒙特利尔认知评估量表（MoCA）对2组患者进行认知功能评估。采用随机数字表法将PD+OSA患者分成2组：治疗性CPAP组（tCPAP）和安慰性CPAP组（pCPAP）,tCPAP组接受治疗性CPAP 6周，pCPAP组先接受安慰性CPAP治疗3周，后转为治疗性CPAP 3周，收集2组患者的一般基线资料、治疗3周及6周的神经、认知测试结果。结果 共纳入92例PD患者，筛选出44例PD+OSA患者与48例PD-OSA患者，PD+OSA患者在MMSE和MoCA测试中的得分低于PD-OSA患者，但差异无统计学意义（P>0.05）。tCPAP组和pCPAP组患者治疗3周、6周时认知功能差异无统计学意义（P>0.05）。与基线相比，所有患者在接受CPAP治疗3周后，综合评分无统计学差异（P>0.05）。结论 在PD患者中，伴OSA患者在认知功能评估中表现较差。经CPAP治疗3周或6周后，OSA的改善可能不足以提升PD患者的整体认知功能。更多还原

【Abstract】 Objective To assess the differences in cognitive function between Parkinson’s disease(PD)patients with obstructive sleep apnea(OSA)(PD+OSA)and patients without OSA(PD-OSA), and observe the improvement of cognitive function in patients with PD + OSA by continuous positive airway pressure(CPAP)treatment.Methods PD patients admitted to the Fifth Affiliated Hospital of Zhengzhou University from April2022 to April 2024 were consecutively included, and patients diagnosed with PD + OSA and PD-OSA were screened by nocturnal polysomnography, and cognitive functions were assessed by the mini-mental status examination(MMSE)and Montreal cognitive assessment(MoCA)scales for the two groups. Patients with PD +OSA were divided into two groups by randomized numeric table method: therapeutic CPAP group(tCPAP)and placebo CPAP group(pCPAP), the tCPAP group received therapeutic CPAP for 6 weeks, and the pCPAP group received placebo CPAP for 3 weeks, and then switched to therapeutic CPAP for 3 weeks, and the general baseline data, the results of neurocognitive tests for the 3 and 6 weeks of treatment, neurocognitive test results at 6 weeks of the two groups were collected.Results A total of 92 patients with PD were included, and 44 patients diagnosed with PD + OSA versus 48 patients with PD-OSA were screened. Patients with PD + OSA scored significantly lower than patients with PD-OSA on the MMSE and MoCA tests, but the differences were not statistically significant(P>0.05). The difference in cognitive functioning between the tCPAP group and the pCPAP group was not statistically significant at 3 and 6 weeks after treatment(P>0.05). Compared with baseline,there was no statistically significant difference in the composite scores of all patients after 3 weeks of CPAP treatment(P>0.05).Conclusion Among patients with PD, those with OSA perform poorly on cognitive function assessments. Improvement in OSA after 3 or 6 weeks of treatment with CPAP may not be sufficient to enhance overall cognitive function in patients with PD.更多还原