【摘要】 目的 探讨健康成年男性体成分与骨密度的关系，为制定科学合理的骨骼健康管理干预策略提供理论依据。方法 选取2023-05～10月在齐齐哈尔某医院进行健康体检的1 325名成年男性为研究对象，根据中国成年人体质量指数(body mass index, BMI)分类标准，将受试者分为正常体质量组(n=608)和超重/肥胖组(n=717)。收集两组受试者基本信息，采用生物电阻抗分析法(bioelectrical impedance analysis, BIA)测定体成分，运用骨定量超声(quantitative ultrasound, QUS)测量受试者骨密度水平。采用Pearson/Spearman相关分析探讨体成分与骨密度的相关性。结果 两组受试者基本资料比较，超重/肥胖组年龄、体质量、BMI、饮酒百分比均高于正常体质量组，规律运动频率低于正常体质量组(P均<0.05)。体成分分析表明，超重/肥胖组受试者身体总水分、蛋白质含量、矿物质含量、体脂肪含量、去脂体质量、骨骼肌质量(skeletal muscle mass, SMM)、体脂百分比、腰臀比、骨骼肌指数(skeletal muscle index, SMI)和各部位(右上肢、左上肢、躯干、右下肢、左下肢)体脂肪含量均显著高于正常体质量组(P均<0.001)。骨密度状况方面，超重/肥胖组受试者超声衰减系数(broadband ultrasound attenuation, BUA)值显著高于正常体质量组(P<0.05)。相关性分析显示，正常体质量组受试者体脂肪含量、体脂百分比、腰臀比和各部位体脂肪含量与定量超声指数(quantitative ultrasound index, QUI)呈弱负相关(P均<0.01),SMI与QUI呈弱正相关(P<0.01);超重/肥胖组受试者除BMI与QUI无相关性(P>0.05),身体总水分、蛋白质含量、矿物质含量、体脂肪含量、去脂体质量、SMM、体脂百分比、腰臀比、SMI和各部位体脂肪含量均与QUI存在弱相关性(P均<0.01)。结论 体成分对骨密度的调控具有体质量状态差异性。健康成年男性骨密度随体脂含量增加而降低，随肌肉质量增加而升高。更多还原

【Abstract】 Objective To investigate the relationship between body composition and bone mineral density in healthy adult males, and provide the theoretical basis for formulating scientific and rational intervention strategies for bone health management.Methods A total of 1 325 adult males who underwent health examinations at a hospital in Qiqihar city from May to October 2023 were selected, the participants were divided into normal body mass group(n=608) and overweight/obesity group(n=717) according to the Chinese body mass index(BMI) classification criteria for adults. Body compositions of the participants were measured using bioelectrical impedance analysis(BIA), while bone mineral density levels were assessed via quantitative ultrasound(QUS). Pearson/Spearman correlation analysis were employed to investigate association between body composition and bone density. Results In the basic data of participants in two groups, age, body weight, BMI and percentage of alcohol consumed in overweight/obese group were higher than those in normal body mass group, and regular exercise frequency was lower than that in normal body mass group(all P<0.05). Body composition analysis showed that total body water, protein content, mineral content, body fat content, fat-free mass, skeletal muscle mass(SMM), body fat percentage, waist hip rate, skeletal muscle index(SMI) and body fat content of each part(right upper limb, left upper limb, trunk, right lower limb and left lower limb) in overweight/obese group were significantly higher than those in normal body mass group(all P<0.001). In terms of bone mineral density status, broadband ultrasound attenuation(BUA) value in overweight/obese group was significantly higher than that in normal body mass group(P<0.05). Correlation analysis showed that body fat content, body fat percentage, waist hip rate and body fat content of each part were weakly negatively correlated with quantitative ultrasound index(QUI) in normal body mass group(all P <0.01). SMI was weakly positively correlated with QUI(P<0.01); in the overweight/obese group, except BMI, QUI were not correlated(P>0.05), total body water, protein content, mineral content, body fat content, fat-free mass, SMM, body fat percentage, waist hip rate, SMI and body fat content of each part were weakly correlated with QUI(all P<0.01). Conclusion The regulation of bone mineral density by body composition exhibits body mass status-dependent differences. In healthy male adults, bone mineral density decreases with increasing body fat mass and increases with elevated muscle mass.更多还原