【摘要】 目的 分析胎盘绒毛膜血管瘤病(CM)的临床病理特征及预后情况。方法 收集信阳市平桥区妇幼保健院2022年9月至2024年2月经病理诊断的7例胎盘CM患者临床病理资料，并对产妇及新生儿健康状况随访。病变组织行免疫组化染色检测平滑肌肌动蛋白(SMA)标记血管周细胞，并复习相关文献。结果 7例胎盘CM均属于局限型(6例局灶性和1例部分性),镜下见绒毛内毛细血管、血管周细胞和间质细胞增生，均未形成结节。孕产妇均出现并发症，包括子痫前期、妊娠期糖尿病、胎盘早剥、妊娠期肝内胆汁淤积症、羊水过少等；不良妊娠结局：包括胎儿宫内发育迟缓、早产、新生儿窒息、高占比的新生儿被收住新生儿重症监护病房。病变区域血管周细胞SMA阳性。产妇及新生儿随访至今均健康存活。结论 胎盘CM准确病理诊断、分型很重要，局限型胎盘CM常合并孕产妇并发症及不良妊娠结局，不影响母儿预后。更多还原

【Abstract】 Objective To study the clinicopathological features and prognosis of placental chorangiomatosis(CM). Methods The clinicopathological data of 7 patients with placental CM diagnosed by pathology in the Pingqiao Maternal and Child Health Hospital from September 2022 to February 2024 were collected, and the health status of the mothers and newborns were followed up. Perivascular cells were labeled by SMA immunohistochemical staining in all the pathological tissues. And the relevant literature was reviewed. Results Seven patients with placental CM were localized(six focal and one partial). Histopathological examination revealed increased numbers of capillaries within chorionic villi accompanied by proliferation of surrounding pericytes and stromal elements, with no evidence of nodular configuration. All maternal patients were complicated by multiple obstetric disorders encompassing pregnancy-induced hypertension, glucose intolerance meeting diagnostic criteria for gestational diabetes, premature placental separation, pruritic cholestatic hepatopathy specific to gestation, and reduced amniotic fluid volume. Neonatal outcomes were marked by growth restriction in utero, premature delivery prior to term completion, perinatal respiratory distress requiring resuscitation, and a statistically significant elevation in neonatal intensive care admissions. Immunohistochemical profiling confirmed characteristic smooth muscle actin(SMA) expression in perivascular cells at lesional sites. Longitudinal monitoring demonstrated sustained well-being in both maternal and infant subjects throughout the surveillance period. Conclusion Accurate pathological diagnosis and classification of placental CM are very important. Localized placental CM is often associated with maternal complications and adverse pregnancy outcomes, and does not affect the prognosis of mother and child.更多还原