【摘要】 目的：探讨不同肌少症状态与中老年人认知功能的关系。方法：采用中国健康与养老追踪调查数据库（CHARLS,2013—2015）的数据。根据2019年亚洲肌少症工作组（AWGS 2019）的标准，肌少症状态分为3种类型：无肌少症、可能肌少症和肌少症。认知功能包括执行功能和情景记忆。两组数据认知得分差值>0定义为认知功能下降。采用多元线性回归分析肌少症与认知功能之间的横断面关系。采用logistic回归分析肌少症与认知功能下降之间的纵向关系。结果：在横断面研究中，可能肌少症和肌少症与执行功能和情景记忆评分呈负相关（P<0.001），且肌少症组比可能肌少症组评分更低，回归系数（95%CI）分别为-0.42 (-0.62,-0.21),-0.33 (-0.46,-0.21);-0.64 (-0.94,-0.34),-0.41(-0.59,-0.23)。在纵向分析中，可能肌少症和肌少症均与情景记忆下降呈正相关，OR (95%CI)分别为1.12 (1.02,1.24),1.23 (1.07,1.41)。结论：采用AWGS 2019标准评估的可能肌少症与肌少症是中国中老年人认知功能下降的独立预测因素，增加了情景记忆下降风险。更多还原

【Abstract】 Objective:To explore the association of sarcopenia on different cognitive domains of middle-aged and elderly people.Methods:Using data from China Health and Elderly Care Tracking Survey Database(CHARLS, from 2013 to 2015).Based on the Asian Working Group for Sarcopenia 2019(AWGS 2019) criteria, sarcopenia status was classified into three types:no-sarcopenia, possible sarcopenia and sarcopenia. If the difference in cognitive scores between two waves of data was >0, it is defined as a decrease in cognitive function. Multivariate linear regression model were used to analyze the cross-sectional relationship between sarcopenia and different cognitive functions. Logistic regression model was used to analyze the longitudinal correlation between sarcopenia and cognitive decline.Results:In cross-sectional studies, possible sarcopenia and sarcopenia were negatively correlated with executive function and episodic memory scores(P<0.001), and the sarcopenic group had lower scores than the possible sarcopenic group. β(95%CI) values were-0.42(-0.62,-0.21),-0.33(-0.46,-0.21);-0.64(-0.94,-0.34),-0.41(-0.59,-0.23), respectively. In the longitudinal analysis, both possible sarcopenia and sarcopenia were positively associated with decreased episodic memory, the OR(95%CI) values were 1.12(1.02,1.24), 1.23(1.07,1.41), respectively.Conclusion:Possible sarcopenia and sarcopenia assessed by AWGS 2019 criteria are independent predictors of cognitive decline in middle-aged and elderly Chinese, increasing their risk of episodic memory decline.更多还原