【摘要】 目的 探讨老年2型糖尿病患者认知衰弱与社会隔离及认知储备的相关性，为开展针对性干预以延缓患者认知衰弱进展提供参考。方法 便利抽取老年2型糖尿病患者608例，采用一般资料调查表、衰弱量表、简易精神状态检查量表、Lubben社会网络量表-6、认知储备指数问卷进行调查。结果 老年2型糖尿病患者认知衰弱发生率为27.0%,社会隔离发生率为31.3%,认知储备总分81.0(74.0,96.0)。相关性分析显示，认知衰弱与社会隔离总分及认知储备总分呈负相关(均P<0.05);社会隔离总分与认知储备总分呈正相关(P<0.05)。多因素logistic回归分析结果显示，文化程度、个人月收入、并存慢病数量、多重用药、夜间睡眠时间、社会隔离及认知储备是老年2型糖尿病患者认知衰弱的影响因素(均P<0.05)。结论 老年2型糖尿病患者认知衰弱、社会隔离发生率较高，认知储备较低。社会隔离风险越高、认知储备越低的患者认知衰弱发生率越高。医护人员需关注老年2型糖尿病患者社会隔离及认知储备状况并加强干预，以预防老年糖尿病患者认知衰弱。更多还原

【Abstract】 Objective To explore the relationship between cognitive frailty, social isolation and cognitive reserve in elderly patients with type 2 diabetes mellitus, and to provide a reference for developing targeted intervention to delay the progression of cognitive decline in patients.Methods Six hundred and eight elderly patients with type 2 diabetes were conveniently selected, then they were investigated by using a general information questionnaire, the Frailty Scale, the Mini-Mental State Examination, the Lubben Social Network Scale-6, and the Cognitive Reserve Index questionnaire.Results The incidence of cognitive frailty in the participants was 27.0%, the incidence of social isolation was 31.3%, and the total score of cognitive reserve was 81.0(74.0,96.0) points.Correlation analysis showed that, cognitive frailty was negatively correlated with the risk of social isolation, and negatively correlated with cognitive reserve(all P<0.05); the risk of social isolation was positively correlated with cognitive reserve(P<0.05).The results of multivariate logistic regression analysis showed that, education, monthly income, the number of chronic diseases, polypharmacy, sleep duration at night, social isolation and cognitive reserve were the influencing factors of cognitive frailty in elderly patients with type 2 diabetes(all P<0.05).Conclusion The incidence of cognitive frailty and social isolation in the elderly patients with type 2 diabetes are high, and their incidence of cognitive reserve is low.The patients with higher risk of social isolation and lower cognitive reserve, are prone to have higher incidence of cognitive frailty.Healthcare professionals should pay attention to the social isolation and cognitive reserve status of elderly patients with type 2 diabetes and strengthen interventions to prevent their cognitive frailty.更多还原