【摘要】 作为一种环境内分泌干扰物，全氟和多氟烷基物质（per-and polyfluoroalkyl substances,PFAS）对人体健康和生态环境的影响受到广泛关注。多项研究结果支持孕期暴露于PFAS会对母体及子代产生多种不良影响，尤其孕期接触PFAS会影响母体的代谢平衡，增加妊娠期糖尿病（gestational diabetes mellitus,GDM）的发生风险。笔者综述了有关PFAS暴露与GDM的流行病学研究结果及PFAS作用的潜在机制，包括其可能通过对激素受体的干扰、激活过氧化物酶体增殖物激活受体γ(PPARγ)和α(PPARα)、干扰PI3K/AKT通路及脂肪因子水平等方面来影响血糖稳态，为今后深入研究PFAS的健康影响以及预防GDM提供思路。更多还原

【Abstract】 As an environmental endocrine disruptor,the impact of per-and polyfluoroalkyl substances(PFAS) on human health and the ecological environment has received extensive attention. The results of multiple studies support that exposure to PFAS during pregnancy can have a variety of adverse effects on the mother and offspring,especially the exposure to PFAS during pregnancy will affect the metabolic balance of the mother and increase the risk of gestational diabetes mellitus(GDM). This paper reviewed the epidemiological findings of PFAS exposure and GDM and the potential mechanisms of PFAS action,including its possible impact on blood glucose homeostasis by interfering with hormone receptors,activating peroxisome proliferator-activated receptor γ(PPARγ) and α(PPARα),interfering with PI3K/AKT pathway and adipokine levels,so as to provide ideas for further research on the health effects of PFAS and the prevention of GDM in the future.更多还原