【摘要】 目的:探讨2型糖尿病（T2DM）患者糖脂代谢相关指标与骨质疏松的相关关系。方法:选择大于50岁的男性T2DM患者及绝经后女性T2DM患者共404例（男性181例，女性223例，）应用双能X射线骨密度仪检测患者腰椎（L₁～L₄）、股骨颈及全髋的骨密度，并根据T值水平分成3个亚组：骨量正常组185例、骨量减少组131例、骨质疏松组88例。测定所有患者糖脂代谢相关指标，计算TyG指数，比较各组间指标的差异。结果:男性患者中，骨量正常组TyG指数高于骨量减少和骨质疏松组（F=3.251,P=0.041）,女性患者中，骨量正常组TyG指数高于骨量减少和骨质疏松组（F=5.591,P=0.004）,骨量正常组患者尿酸水平高于骨量减少和骨质疏松组（F=17.203,P<0.001）;Logistic回归分析显示，TyG指数是大于50岁的男性T2DM患者骨质疏松的保护性因素（OR=0.405,P=0.049）;TyG指数（OR=0.834,P<0.001）和尿酸（OR=0.991,P<0.001）是绝经后女性T2DM患者骨质疏松的保护性因素。结论:TyG指数是大于50岁男性T2DM患者和绝经后女性T2DM患者骨质疏松的保护性因素，尿酸是绝经后女性T2DM患者骨质疏松的保护性因素。更多还原

【Abstract】 Objective:To explore the correlation between indicators related to glucose and lipid metabolism and osteoporosis in patients with type 2 diabetes mellitus（T2DM）.Methods: A total of 404 T2DM patients, including 181 males over 50 years old and 223 postmenopausal females, were selected. Dual-energy X-ray absorptiometry（DXA） was used to detect bone mineral density（BMD） of the lumbar spine（L₁～L₄）, femoral neck, and total hip. According to the T-score, patients were divided into three subgroups: normal group（185 cases）, osteopenia group（131 cases）, and osteoporosis group（88 cases）. Indicators related to glucose and lipid metabolism were measured, and the TyG index was calculated to compare differences among groups. Results:In male patients, TyG index in the normal group was higher than that in the osteopenia and osteoporosis group（F=3.251, P=0.041）; and in female patients, TYG index in the normal group was higher than that in the osteopenia and osteoporosis group（F=5.591, P=0.004）, the uric acid in normal group was higher than that in the osteopenia and osteoporosis group（F=17.203, P<0.001）. Logistic regression analysis showed that the TyG index was a protective factor for osteoporosis in male T2DM patients over 50 years old（OR = 0.405, P = 0.049）. TyG index（OR = 0.834,P<0.001） and uric acid（OR = 0.991, P<0.001） were the protective factors for osteoporosis in postmenopausal women with T2DM. Conclusion:TyG index is a protective factor for osteoporosis in male T2DM patients over 50 years old and in postmenopausal women, and uric acid is a protective factor for osteoporosis in postmenopausal women with T2DM.更多还原