【摘要】 目的 观察新蒲饮联合抗幽门螺杆菌(Hp)四联疗法治疗脾胃湿热型慢性自发性荨麻疹(CSU)的临床疗效。方法 将105例脾胃湿热型CSU患者按照随机数字表法分为2组，2组均予CSU常规治疗，对照组52例联合抗Hp四联疗法，治疗组53例在对照组基础上联合新蒲饮治疗。比较2组治疗4周后疗效、疾病活动度[7 d荨麻疹活动度评分(UAS7)]、疾病控制率、Hp转阴率、实验室指标[白细胞介素2(IL-2)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、免疫球蛋白(Ig E)、干扰素γ(IFN-γ)、白三烯B4(LTB4)]及不良反应。结果 治疗组总有效率90.57%(48/53)，对照组总有效率73.08%(38/52)，治疗组临床疗效优于对照组(P<0.05)。2组治疗后UAS7评分均较本组治疗前降低(P<0.05)，且治疗组治疗后低于对照组(P<0.05)。治疗组疾病控制率、Hp转阴率均高于对照组(P<0.05)。2组治疗后血清IL-2、TNF-α、CRP、Ig E、LTB4水平均较本组治疗前降低(P<0.05),IFN-γ水平均升高(P<0.05)，且治疗组治疗后血清IL-2、TNF-α、CRP、Ig E、LTB4水平均低于对照组(P<0.05),IFN-γ水平高于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论 新蒲饮联合抗Hp四联疗法治疗脾胃湿热型CSU疗效确切，能降低疾病活动度，提高疾病控制率、Hp转阴率，抑制炎症反应并调节免疫，未增加药物不良反应。更多还原

【Abstract】 Objective To observe the clinical efficacy of Xinpu Decoction combined with anti-Helicobacter pylori( Hp)quadruple therapy for chronic spontaneous urticaria( CSU) of spleen-stomach damp heat type. Methods A total of 105 patients with CSU of spleen-stomach damp heat type were randomly assigned to receive conventional treatment + anti-Hp quadruple therapy( the control group,n = 52) or conventional treatment + anti-Hp quadruple therapy + Xinpu Decoction( the treatment group,n = 53) for 4 weeks. The efficacy,disease activity( 7-day urticaria activity score [UAS7]),disease control rate,Hp negative rate,laboratory indicators( interleukin-2 [IL-2],tumor necrosis factor α [TNF-α],C-reactive protein [CRP],immunoglobulin E [Ig E],interferon-gamma( IFN-γ) and leukotriene B4 [LTB4]),and adverse reactions were included as comparators. Results The overall effective rate in the treatment group was significantly higher than that in the control group( 90.57% [48/53]vs 73.08% [38/52],P< 0.05). After treatment,the UAS7 scores in the both groups were significantly decreased( P< 0. 05),which were significantly lower in the treatment group than in the control group( P < 0.05). The disease control rate and Hp negative rate in the treatment group were significantly higher than those in the control group( P<0.05). After treatment,significantly decreased IL-2,TNF-α,CRP,Ig E,and LTB4 levels,and increased IFN-γ levels were found in the both groups( all P<0.05),and the treatment group was superior to the control group for IL-2,TNF-α,CRP,Ig E,LTB4,and IFN-γlevels( all P< 0.05). The incidence of adverse reactions between groups was comparable( P>0.05). Conclusion Xinpu Decoction combined with anti-Hp quadruple therapy has a definite therapeutic effect in patients with CSU of spleen-stomach damp heat type,which can reduce disease activity,improve disease control rate and Hp negative rate,inhibit inflammatory response and regulate immunity,and it does not increase adverse drug reactions.更多还原