【摘要】 目的 观察珠香散与新型敷料联合艾灸治疗3期压力性损伤(PI)的临床疗效。方法 选择2023年1月至2024年6月收治的100例3期PI患者为研究对象，按照抽签法随机分为研究组与对照组，各50例。对照组予常规干预治疗，研究组在对照组的基础上应用珠香散与新型敷料联合艾灸干预治疗。2组连续干预治疗14 d后观察恢复效果，比较2组治疗前后压疮愈合评分表(PUSH)评分(包括损伤面积、渗液量、组织类型)、疼痛视觉模拟评分法(VAS)评分、炎症因子[包括C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]水平变化情况，比较2组治疗期间的换药次数、伤口愈合时间、满意率情况，比较2组患者治疗期间不良反应发生情况。结果 与本组治疗前比较，2组治疗后PUSH创面面积、渗液量、组织类型评分及总分均降低(P<0.05)，且研究组治疗后PUSH创面面积、渗液量、组织类型评分及总分均低于对照组(P<0.05)。与本组治疗前比较，2组治疗后疼痛VAS评分均降低(P<0.05)，且研究组治疗后疼痛VAS评分低于对照组(P<0.05)。与本组治疗前比较，2组治疗后炎症因子CRP、IL-6、TNF-α水平均降低(P<0.05)，且研究组治疗后炎症因子CRP、IL-6、TNF-α水平均低于对照组(P<0.05)。研究组治疗期间换药次数少于对照组(P<0.05)，伤口愈合时间短于对照组(P<0.05)，满意率高于对照组(P<0.05)。研究组总有效率96.00%(48/50)，对照组总有效率82.00%(41/50)，研究组总有效率高于对照组(P<0.05)。研究组不良反应总发生率4.00%(2/50，对照组不良反应总发生率16.00%(8/50)，研究组不良反应总发生率低于对照组(P<0.05)。结论 珠香散与新型敷料联合艾灸可促进3期PI创面康复，缩短创面愈合时间，减轻炎症反应，安全性良好。更多还原

【Abstract】 Objective To investigate the clinical efficacy of Zhuxiang Powder and new dressings combined with moxibustion in the treatment of stage 3 pressure injury( PI). Methods A total of 100 stage 3 PI patients treated in our hospital from January 2023 to June 2024 were recruited. The patients were equally divided into a study group and a control group using a random drawing method. All patients received routine intervention,those in the study group added Zhuxiang Powder and new dressings combined with moxibustion for 14d. The Pressure Ulcer Scale for Healing( PUSH) score( including injury area,exudation volume,tissue type),pain visual analogue scale( VAS) score,and inflammatory factors( including C-reactive protein[CRP],interleukin-6 [IL-6],tumor necrosis factor-α [TNF-α]) were compared between the two groups before and after treatment. The frequency of dressing change,wound healing time,satisfaction,and treatment-emergent adverse events( TEAEs)were compared between the two groups. Results After intervention,the scores of PUSH and VAS in both groups significantly decreased compared to those before intervention( both P < 0. 05),and the study group was more lower than the control group( both P<0.05). The expression levels of CRP,IL-6,and TNF-αin both groups significantly decreased compared to those before intervention,and the study group was more lower than the control group( P < 0. 05). The frequency of dressing change and wound healing time in the study group were significantly decreased than those in the control group( both P<0.05),and the satisfaction level was significantly higher than that in the control group( P<0.05). The total effective rate in the study group was significantly higher than that of the control group( 96. 00%[48/50] vs82.00%[41/50],P<0.05). The incidence of TEAEs in the study group was significantly lower than that in the control group( 4.00% [2/50] vs 16. 00% [8/50],P < 0. 05). Conclusion The combination of Zhuxiang Powder new dressings with moxibustion can promote the recovery of stage 3 PI wounds,shorten wound healing time,reduce the degree of inflammatory response,with a better safety.更多还原