【摘要】 以邻氨基苯酚、β-环状二酮、芳香醛为原料，无水乙醇为溶剂，对甲苯磺酸为催化剂，通过三组分串联反应一锅合成了5种新型的多环稠合1,5-苯并氧氮杂■化合物.该串联反应实现了在一个反应体系中构建同时含有O,N杂原子的七元环和4个新化学键■和C—C),并提出了2种可能的反应机理.该方法具有反应条件温和、绿色环保、操作简单、产率优良等优点，为多环稠合1,5-苯并氧氮杂■化合物的制备提供了新的参考方法.更多还原

【Abstract】 Using o-aminophenol, β-cyclic diketones and aromatic aldehydes as raw materials, anhydrous ethanol as solvent, and p-toluenesulfonic acid as catalyst, five new types of polycyclic 1,5-benzoxazepines were synthesized by one-pot three-component tandem reaction.This tandem reaction achieved the synthesis of seven-membered rings containing both oxygen and nitrogen heteroatoms, along with four new chemical bonds■ reaction system.Additionally, two possible reaction mechanisms were proposed.This method has advantages including simple and mild reaction conditions, environmental friendliness, and high yields, which provides a novel reference for the synthesis of polycyclic 1,5-benzoxazepine compounds.更多还原