【摘要】 为了提高激光手术效率和减少激光手术中对周围健康组织的损伤，探究了脉冲钬激光脉冲峰值功率、连续铥激光功率对于软组织热效应的影响。搭建体外模型装置来寻求激光消融组织的最佳参数，实验中脉冲钬激光功率分别为20W、40W、60W、80W,脉冲持续时间为200μs和800μs,脉冲能量分别选择1J、2J、4J。连续铥激光功率分别为20W、40W、60W、80W、100W、110W。最后，将体外模型置于生理盐水中，保持室温一定，对激光消融后的损伤组织进行切片和染色，分析病理切片。脉冲峰值功率对软组织的消融区产生较大影响，脉冲能量为4J×10Hz的激光组合比1J×40Hz的激光组合产生的消融深度提高111.82%,对凝固区的影响不大，改变仅为9.96%。脉冲持续时间对软组织的影响不大，脉宽较短产生的消融深度提高18.49%。组织消融深度随连续铥激光的功率提高而提高，消融效率也相应提高，热凝固区几乎不受影响。100W的消融效率比20W提高88.26%。更多还原

【Abstract】 In order to improve the efficiency of laser surgery and reduce the damage to surrounding healthy tissues during laser surgery, the influence of the peak power of pulsed holmium laser and continuous thulium laser power on the thermal effect of soft tissues was explored. Build an in vitro model device to find the optimal parameters for laser ablation of tissue, the pulsed holmium laser power is 20W, 40W, 60W, 80W, the pulse duration is 200μs and 800μs, and the pulse energy is 1J, 2J, 4J. The continuous thulium laser power is 20W, 40W, 60W, 80W, 100W, 110W. Finally, the in vitro model was placed in physiological saline and kept at a constant room temperature for experiments. The damaged tissue after laser ablation was sliced and stained, and pathological slices were analyzed. The peak pulse power has a great influence on the ablation zone of soft tissue. The ablation depth of the laser combination with the pulse energy of 4J×10Hz is 111.82% higher than that of the laser combination with the pulse energy of 1J×40Hz, while the effect on the solidification zone is only 9.96%. Pulse duration had little effect on soft tissue, and ablation depth was increased by 18.49% with shorter pulse width. The ablation depth of tissue increases with the increase of the power of continuous thulium laser, and the ablation efficiency is correspondingly increased, and the hot solidification zone is almost unaffected. The ablation efficiency of 100W is nearly 88.26% higher than that of 20W.更多还原