【摘要】 采用静态法测定了常压下α-酮戊二酸在水、乙酸乙酯、乙酸正丁酯和丙酮酸中的溶解度，并研究了丙酮酸对α-酮戊二酸在水、乙酸乙酯、乙酸正丁酯3种溶剂中溶解度的影响。实验结果表明：α-酮戊二酸在水-丙酮酸、乙酸乙酯-丙酮酸、乙酸正丁酯-丙酮酸3种混合溶剂中的溶解度总体与温度呈正相关；在水-丙酮酸混合溶剂中，丙酮酸摩尔比（y1）增大会使α-酮戊二酸的溶解度减小；在乙酸乙酯-丙酮酸、乙酸正丁酯-丙酮酸混合体系中，丙酮酸摩尔比增加会使α-酮戊二酸的溶解度先减小后增大，两体系极小值分别位于乙酸乙酯-丙酮酸摩尔比y2=0.60和乙酸正丁酯-丙酮酸摩尔比y3=0.47附近。Apelblat方程、Yaws方程和（CNIBS）/Redlich-Kister方程对α-酮戊二酸在以上3种混合溶剂中的溶解度数据关联良好；采用修正的van′t Hoff方程计算了α-酮戊二酸在水-丙酮酸、乙酸乙酯-丙酮酸、乙酸正丁酯-丙酮酸3种混合体系的溶解焓、溶解熵和吉布斯自由能。研究结果为建立α-酮戊二酸的生产工艺提供基础数据。更多还原

【Abstract】 The solubility of α-ketoglutarate（α-KG） in water,ethyl acetate （EA）,n-butyl acetate （nBA） and pyruvate （PYR） under normal pressure was determined by a static method.Effects of PYR on the solubility of α-KG in water,EA and nBA was studied.The results show that the solubility of α-KG in water-PYR,EA-PYR and nBA-PYR is positively correlated with temperature.In water-PYR mixture solvents,the solubility of α-KG decreases with the increase of the molar ratio of pyruvate （y₁）.In the EA-PYR and nBA-PYR mixed solvents,the solubility decreases first and then increases with the increase of the molar ratio of PYR,and the minimum values are near y₂=0.60 andy₃=0.47,respectively.Apelblat model,Yaws model and （CNIBS）/Redlich-Kister equation correlate well with the solubility data of α-KG in the three mixed solvents.The Thermodynamic parameters(Δ_solH_m^°，Δ_solS_m^°andΔ_solG_m^°)of α-KG in above three systems were calculated by modified van′t Hoff equation.更多还原