【摘要】 目的 观察舒肝顺气丸治疗功能性消化不良(FD)伴焦虑或抑郁症状(肝郁气滞证)患者的临床效果并探讨其作用机制。方法 选取2021年9月—2022年9月重庆某医院诊治的FD患者46例为研究对象,给予舒肝顺气丸治疗4周。观察疗效并比较治疗前后患者FD症状评分、中医证候评分、焦虑症状评分[采用广泛性焦虑量表(GAD-7)评分]及抑郁症状评分[采用患者健康问卷抑郁量表(PHQ-9)评分],记录患者不良事件发生情况。结果 治疗后,患者总体疗效总有效率、FD疗效总有效率、中医证候疗效总有效率分别为60.87%、63.05%和78.26%;患者焦虑和抑郁症状明显改善,总有效率分别达到了93.48%和100.00%;FD单项症状如餐后饱胀不适、早饱不适感、中上腹痛和中上腹烧灼感的总有效率分别为58.70%、86.96%、73.91%、93.48%。治疗后,患者FD症状、中医证候、GAD-7、PHQ-9评分和中医证候单项评分均较治疗前有所下降,差异有统计学意义(均P<0.05)。治疗后,患者焦虑和抑郁症状等级分布均较治疗前有所改善,差异有统计学意义(均P<0.05)。治疗期间均无严重不良反应事件发生。结论 舒肝顺气丸对FD伴焦虑或抑郁症状(肝郁气滞证)安全有效,可改善患者焦虑、抑郁症状,提高生活质量。更多还原

【Abstract】 Objective To observe the therapeutic efficacy of Shugan Shunqi Pills in the treatment of functional dyspepsia(FD)with anxiety or depressive symptoms(liver Qi stagnation syndrome) and to explore its mechanism.Methods A total of 46 patients diagnosed with FD from a hospital in Chongqing between September 2021 and September 2022 were selected as study participants.They were treated with Shugan Shunqi Pills for 4 weeks.The therapeutic efficacy was observed,and the patients’ FD symptom scores,Traditional Chinese Medicine(TCM)syndrome scores,anxiety symptom scores(measured using the Generalized Anxiety Disorder Scale,GAD-7),and depression symptom scores(measured using the Patient Health Questionnaire Depression Scale,PHQ-9) were compared before and after treatment.Adverse events were recorded.Results After treatment,the overall response rates of overall therapeutic efficacy,FD therapeutic efficacy,and TCM syndrome therapeutic efficacy of the patients were 60.87%,63.05 %,and 78.26 %,respectively.The anxiety and depression symptoms showed significant improvement,with overall response rates reaching 93.48 % and 100.00 %,respectively.The overall response rates for individual FD symptoms,such as postprandial fullness,early satiety,epigastric pain,and epigastric burning,were 58.70 %,86.96 %,73.91 %,and 93.48%,respectively.After treatment,the FD symptoms,TCM syndrome scores,GAD-7,PHQ-9 scores,and individual TCM syndrome scores all decreased significantly compared to before treatment,with statistically significant differences(P<0.05).The distribution of anxiety and depression symptom levels also showed significant enhancement,with differences reaching statistical significance(P<0.05).No serious adverse events occurred during the treatment.Conclusion Shugan Shunqi Pills are safe and effective for treating FD with anxiety or depressive symptoms(liver Qi stagnation syndrome).It can alleviate patients’ anxiety and depression symptoms and raise their quality of life.更多还原