【摘要】 目的 基于定量CT(QCT)体成分测量,分析内脏脂肪面积(VFA)与代谢综合征(Met S)之间的相关性。方法 回顾性分析2020年7月—2022年7月于重庆医科大学第二附属医院健康医学中心行QCT体成分测量的5 950名体检对象的体检资料,其中男性3 317人,女性2 633人。采用QCT测量体验对象VFA、肝脏脂肪含量(LFC),并收集其身高、体质量、身体质量指数(BMI)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清尿酸(SUA)、空腹血糖(FBG)等一般临床资料。分性别分析Mets患者和非Mets者VFA的差异;采用多因素logstic回归逐步调整混杂因素,并构建3个预测模型;采用受试者工作特征(ROC)曲线评估3个模型的预测价值。结果 男性Met S患病率(26.56%)明显高于女性(9.99%)。不论在男性还是女性中,Met S组患者年龄、BMI、WC、SBP、DBP、TG、SUA、FBG、LFC均高于非Met S组,HDL-C低于Met S组(P<0.05),TC和LDL-C在2组间差异均无统计学意义(P>0.05);Met S组患者VFA水平明显高于非Met S组,且VFA水平越高,Met S风险越大,该趋势在逐步调整混杂因素后仍然存在(P<0.05);VFA预测Met S效果良好,且在女性中更为显著。结论 VFA可能是Met S的独立危险因素,可用于预测早期Met S,并具有良好的预测效能。更多还原

【Abstract】 Objective To investigate the association between visceral fat area(VFA) and metabolic syndrome(MetS) using quantitative computed tomography(QCT) body-composition measurement. Methods We retrospectively reviewed the health-check data of 5,950 individuals(3,317 men and 2,633 women) who underwent QCT body-composition analysis at the Health Medicine Center of the Second Affiliated Hospital of Chongqing Medical University from July 2020 to July 2022. VFA and liver fat content(LFC) were measured by QCT, and clinical parameters including height, body weight, body mass index(BMI), waist circumference(WC), systolic and diastolic blood pressure(SBP, DBP), triglycerides(TG), total cholesterol(TC), high-density and low-density lipoprotein cholesterol(HDL-C, LDL-C), serum uric acid(SUA), and fasting blood glucose(FBG) were collected. We compared VFA between MetS andnon-MetS groups stratified by sex, performed multivariable logistic regression with stepwise adjustment for confounders to construct three predictive models, and evaluated their performance using receiver operating characteristic(ROC) curves. Results The prevalence of MetS wassignificantly higher in men than in women(26.56% vs. 9.99%). In both sexes, MetS patients were older and had higher BMI, WC, SBP, DBP, TG, SUA, FBG, and LFC, and lower HDL-C compared with non-MetS participants(P<0.05), while TC and LDL-C did not differ significantly between groups(P>0.05). VFA was markedly greater in the MetS group than in the non-MetS group, and higher VFA levels were associated with increased MetS risk; this trend persisted after sequential adjustment for confounders(P<0.05). VFA showed good predictive ability for MetS, with even stronger performance in women. Conclusion VFA appears to be an independent risk factor for MetS andmay serve as a sensitive predictor for early MetS detection, demonstrating robust predictive efficacy.更多还原