【摘要】 目的 分析脑小血管疾病（Cerebral small vessel disease,CSVD）总负荷与抑郁症状的相关性。方法 回顾性分析2021年1月～2024年8月在我院收治的400例CSVD患者的临床资料，依据抑郁症筛查量表（Patient Health Questionnaire-9,PHQ-9）分为抑郁症状组（n=120）和非抑郁症状组（n=280）。比较两组基础资料信息及CSVD总负荷评分，经多因素Logistic回归分析CSVD患者抑郁的危险因素，采用spearman相关性分析CSVD总负荷与抑郁症状的关系。结果 抑郁症状组血红蛋白水平低于非抑郁症状组，CSVD总负荷3～4分患者占比高于非抑郁症状组（P<0.05）；经多因素Logistic回归分析证实，血红蛋白降低、CSVD总负荷是影响CSVD患者抑郁的危险因素（P<0.05）；相关性分析显示，CSVD总负荷与抑郁症状呈正相关（P<0.05）。结论 血红蛋白降低、CSVD总负荷是影响CSVD患者抑郁的危险因素，且随着CSVD总负荷的加重，CSVD患者抑郁症状发生率不断增加。更多还原

【Abstract】 Objective The correlation between total Cerebral small vessel disease(CSVD)burden and depressive symptoms was analyzed. Methods Clinical data of 400 patients with CSVD admitted to our hospital from January 2021 to August 2024 were retrospectively analyzed. According to the Patient Health Questionnaire-9(PHQ-9),the patients were divided into depression symptom group(n=120)and non-depressive symptoms group(n=280). Compare the basic data information of the two groups and the total CSVD burden score. Multivariate Logistic regression was used to analyze the risk factors of depression in CSVD patients,and spearman correlation was used to analyze the relationship between total CSVD burden and depressive symptoms. Results The hemoglobin level of depressive symptom group was lower than that of non-depressive symptom group,and the proportion of patients with 3 to 4 points of CSVD total burden was higher than that of non-depressive symptom group(P<0.05). Multivariate Logistic regression analysis confirmed that decreased hemoglobin and total CSVD burden were risk factors for depression in CSVD patients(P<0.05). Correlation analysis showed that the total CSVD burden was positively correlated with depressive symptoms(P<0.05). Conclusion Decreased hemoglobin and total CSVD burden are risk factors for depression in CSVD patients,and with the aggravation of total CSVD burden,the incidence of depressive symptoms in CSVD patients is increasing.更多还原