【摘要】 目的 探讨围绝经期抑郁患者炎性因子、神经递质水平变化及与抑郁情绪的关系。方法 以2023年2月～2025年1月86例围绝经期女性为观察对象，根据汉密尔顿抑郁量表（Hamilton Depression Scale-17,HAMD-17）评估情况分为抑郁组与非抑郁组，比较两组炎性因子、神经递质水平，并分析与HAMD-17评分的相关性。结果 86例围绝经期女性25例具有抑郁情绪，HAMD-17评分（19.86±2.11）分；抑郁组促炎性因子[白细胞介素-2(Interleukin-2,IL-2)、肿瘤坏死因子（tumor necrosis factor,TNF-α）]水平显著高于非抑郁组，抑炎性因子（IL-4、IL-10）水平显著低于非抑郁组（P<0.05）；抑郁组5-羟色胺（5-hydroxy tryptamine,5-HT）、多巴胺（dopamine,DA）低于非抑郁组（P<0.05）；抑郁组HAMD评分与IL-2、TNF-α呈正相关，与IL-4、IL-10、5-HT、DA呈负相关（P<0.05）。结论 围绝经期抑郁患者存在促炎、抑炎性因子水平失调以及神经递质水平紊乱现象，且与抑郁情绪显著相关。更多还原

【Abstract】 Objective To investigate the changes in the levels of inflammatory factors and neurotransmitters in perimenopausal depressed patients and their relationship with depressed mood. Methods Eighty-six perimenopausal women were observed from February 2023 to January 2025,and were divided into the depressed group and the non-depressed group according to the screening of Hamilton Depression Scale-17(HAMD-17). The levels of inflammatory factors and neurotransmitters were compared between the two groups,and the correlation with the HAMD-17 score was analyzed. Results Twenty-five of 86 perimenopausal women had depressive mood with HAMD-17 score(19.86±2.11). The levels of pro-inflammatory factors[ interleukin-2(IL-2),tumor necrosis factor(TNF-α)] were significantly higher in the depressed group than in the nondepressed group,and the levels of anti-inflammatory factors(IL-4,IL-10)were significantly lower than in the nondepressed group(P<0.05). The levels of 5-hydroxy tryptamine(5-HT)and dopamine(DA)were lower in the depressed group than in the non-depressed group(P<0.05). HAMD scores in the depressed group were positively correlated with IL-2 and TNF-α,and negatively correlated with IL-4,IL-10,5-HT,and DA(P<0.05). Conclusion Perimenopausal depressed patients have dysregulated levels of pro-inflammatory and anti-inflammatory factors as well as disturbed levels of neurotransmitters,which are significantly associated with depressed mood.更多还原