【摘要】 骨折后骨延迟愈合或骨不愈合的常规治疗存在治疗周期长、患者经济负担重等诸多问题，而细胞疗法促进骨折愈合现已成为一种新兴疗法引起了广泛关注和研究。本文汇总巨噬细胞来源外泌体（macrophage-derived exosomes, MD-Exos）介导成骨及成血管促进骨折愈合的相关进展，包括MD-Exos通过促进血管生成、促进血管损伤修复、促进成骨相关因子表达、干预骨髓间充质干细胞以及通过生物制品对骨折愈合的积极作用，以探寻MD-Exos与骨折愈合之间的可能关系，为临床促进骨折愈合及治疗骨不连探索新的治疗方法提供参考。更多还原

【Abstract】 Conventional treatments for delayed union or nonunion after fractures are often associated with long treatment cycles and significant financial burdens for patients. In recent years, cell-based therapies that promote fracture healing have emerged as promising strategies, attracting widespread attention and research interest. This review summarizes recent advances in the role of macrophage-derived exosomes(MD-Exos) in mediating osteogenesis and angiogenesis to promote fracture healing. The review focuses on how MD-Exos facilitate angiogenesis, repair vascular injury, upregulate osteogenesis-related factors, modulate bone marrow mesenchymal stem cells, and exert beneficial effects through various biological products. By exploring the potential relationship between MDEexos and fracture healing, this article aims to provide new insights and therapeutic perspectives for clinical strategies to enhance bone repair and treat bone nonunion.更多还原