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高毒力碳青霉烯类耐药肺炎克雷伯菌感染诊治与防控专家共识

Expert consensus on the diagnosis,treatment,prevention,and control of hypervirulent carbapenem-resistant Klebsiella pneumoniae infection

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【作者】 中国医师协会感染科医师分会; 中华预防医学会医院感染控制分会; 中国医院协会临床微生物实验室专业委员会; 中华医学会细菌感染与耐药防治分会; 中华医学会感染病学分会细菌真菌学组; 国家传染病医学中心(杭州); 国家感染性疾病临床医学研究中心(杭州); 浙江省医师协会感染科医师分会; 浙江省药学会微生物耐药与控制专业委员会; 肖永红; 吴安华; 马筱玲; 王明贵; 张文宏; 李春辉; 肖婷婷; 孟秀娟; 周凯; 罗琦霞; 康海全; 喻玮;

【Author】 Chinese Society of Infectious Disease Physicians,Chinese Medical Doctor Association;Healthcare-associated Infection Control Branch of Chinese Preventive Medicine Association;Chinese Hospital Association Clinical Microbiology Laboratory Specialized Committee;Society of Bacterial Infection and Resistance of Chinese Medical Association;Bacteriology and Mycology Group,Society of Infectious Diseases,Chinese Medical Association;National Medical Center for Infectious Diseases(Hangzhou);National Clinical Research Center for Infectious Diseases(Hangzhou);Infectious Disease Physicians Branch of Zhejiang Medical Doctors Association;Antimicrobial Resistance and Control Committee of Zhejiang Pharmaceutical Association;Xiao Yonghong;Wu Anhua;Ma Xiaoling;Wang Minggui;Zhang Wenhong;The First Affiliated Hospital,Zhejiang University School of Medicine,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases;Xiangya Hospital,Central South University;The First Affiliated Hospital,University of Science and Technology of China;Huashan Hospital,Fudan University;

【通讯作者】 肖永红;吴安华;马筱玲;王明贵;张文宏;

【机构】 浙江大学医学院附属第一医院传染病重症诊治全国重点实验室国家感染性疾病临床医学研究中心; 中南大学湘雅医院; 中国科学技术大学附属第一医院; 复旦大学附属华山医院; 济宁医学院附属医院; 深圳大学; 徐州医科大学附属医院;

【摘要】 高毒力肺炎克雷伯菌(hypervirulent Klebsiella pneumoniae, hvKP)具有独特的表型特征(如高黏液型、特殊血清型)和基因型特征(如携带特殊的毒力基因),临床致病力强。随着细菌耐药的不断演变,高毒力碳青霉烯类耐药肺炎克雷伯菌(hypervirulent carbapenem-resistant Klebsiella pneumoniae, HCKP)的出现,给全球公共卫生及临床感染治疗与防控带来极大挑战。如何早期识别HCKP感染、及时诊治及防控非常重要。本共识就HCKP流行病学、致病与耐药性、临床特征、实验室检查、预防与控制等方面提出专家建议,供临床诊治与防控参考。

【Abstract】 Hypervirulent Klebsiella pneumoniae(hvKP) exhibits unique phenotypes(such as hypermucoviscosity, specific serotypes) and genotypes(such as carrying specific virulence genes), demonstrating strong clinical pathogenicity. With the bacterial convergence evolution, the emergence of hypervirulent carbapenem-resistant Klebsiella pneumoniae(HCKP) poses significant challenges to global public health, as well as to clinical infection treatment and prevention. Early identification, timely diagnosis and treatment, as well as prevention and control of HCKP infection are crucial needs. This consensus aims to provide expert recommendations on the epidemiology, pathogenicity, antimicrobial resistance, clinical characteristics, laboratory testing, as well as prevention and control of HCKP, serving as a reference for diagnosis, treatment, as well as prevention and control of HCKP infections.

【基金】 国家重点研发计划(2024YFC2310800、2024YFE0198900);国家自然科学基金(82202588);深圳市医学研究专项资金项目(B2403002)
  • 【文献出处】 中国感染控制杂志 ,Chinese Journal of Infection Control , 编辑部邮箱 ,2025年12期
  • 【分类号】R446.5
  • 【下载频次】102
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