【摘要】 奥氮平在治疗精神分裂症和双相情感障碍方面具有良好的疗效。然而，奥氮平也是导致代谢失调风险最高的抗精神病药物之一，长期服用可显著增加患者的血糖血脂，造成高血压、糖尿病、肥胖等药物不良反应。针对抗精神病药物所致肥胖的治疗手段多种多样，近年来用中医方法治疗奥氮平诱导的糖脂代谢紊乱的临床和基础研究均取得了显著进展。气血失调是奥氮平诱导药源性肥胖及代谢紊乱的主要病机，部分用于治疗肥胖，调节糖脂代谢紊乱的中药单体、中药复方或针刺治疗可不同程度发挥拮抗奥氮平诱导糖脂代谢紊乱的作用。本文归纳总结了近年来中医药拮抗奥氮平诱导的药源性糖脂代谢紊乱和肥胖的研究成果，以期为奥氮平诱导的糖脂代谢紊乱的治疗药物的临床应用及新药物研发提供参考。更多还原

【Abstract】 Olanzapine is a widely used atypical antipsychotic drug(AAPD) with proven efficacy in treating schizophrenia and bipolar disorder. However, it is also associated with the highest risk of metabolic disturbances among antipsychotic medications. Long-term use can significantly increase patients’ blood glucose and lipid levels, leading to adverse effects such as hypertension, diabetes, and obesity.There are multiple strategies to manage antipsychotic-induced obesity. In recent years, significant progress has been made in both clinical and basic research on the use of traditional Chinese medicine(TCM) to treat olanzapine-induced glucose and lipid metabolic disorders. Qi and blood disharmony is identified as the primary pathophysiological mechanism underlying olanzapine-induced drug-induced obesity and metabolic disturbances. Certain TCM monotherapies, herbal compound prescriptions, or acupuncture treatments used for managing obesity and regulating glucose and lipid metabolism have shown varying degrees of efficacy in counteracting olanzapine-induced glucose and lipid metabolic disturbances. This article summarizes the recent research findings on the use of TCM to antagonize olanzapine-induced drug-induced glucose and lipid metabolic disorders and obesity, aiming to provide a reference for the clinical application of treatments for olanzapine-induced metabolic disturbances and the development of new therapeutic agents.更多还原