【摘要】 目的 ：构建育龄期淋巴瘤患者生育力保护决策辅助方案并应用，以期为临床实践提供借鉴。方法 ：通过证据总结及专家小组会议，在渥太华决策支持框架下构建淋巴瘤生育力保护决策辅助方案。采用便利抽样法，选取2023年7月—9月在浙江省某三级甲等肿瘤专科医院就诊的30例患者为对照组，实施常规护理；选取2023年10月—12月的30例患者为干预组，应用男性和女性版本的生育力保护决策辅助方案，比较两组患者生育力保护措施采取率及决策困境、癌症后生育忧虑及生育力保护相关知识的情况。结果 ：完善首次治疗出院时，干预组3例（10.0%）患者采取生育力保护措施，对照组1例（3.3%）患者采取生育力保护措施，两组差异无统计学意义（χ2=1.071,P=0.301）；完成首次治疗后6个月，干预组决策有效人数占比高于对照组，差异有统计学意义（P<0.05）；完成首次治疗出院时、完成首次治疗后6个月，干预组癌症生育忧虑得分低于对照组、生育力保护相关知识得分高于对照组，差异有统计学意义（均P<0.001）。结论 ：本研究构建的育龄期淋巴瘤患者生育力保护决策辅助方案在一定程度上降低了该类患者的决策困境及癌症后生育忧虑，提高了患者对生育力保护相关知识的了解程度。更多还原

【Abstract】 Objective: To construct a decision-making assistance program for Fertility Preservation(FP) in patients with lymphoma of childbearing age and to explore the effects of this program, aiming to provide references for clinical practice. Methods: Through evidence summary and expert meeting, the decision-making assistance program for FP in lymphoma patients was developed under the Ottawa Decision Support Framework. Using the convenience sampling method, a total of 30 patients who received treatment in a tertiary grade A tumor specialized hospital in Zhejiang province from July to September 2023 were selected as the control group and received routine nursing care. Another 30 patients who received treatment from October to December 2023 were selected as the intervention group and were applied with the FP decision-making assistance program for male or female versions. The adoption rate of FP, decision-making dilemma, postcancer fertility concerns and fertility preservation-related knowledge were compared between the two groups. Results: At discharge after the first treatment, the adoption rate of FP in intervention group and control group were 10.0% and 3.3%,respectively, but without statistically significant difference between the groups(χ2=1.071, P=0.301). At six months after the first treatment, the proportion of patients with effective decision-making in the intervention group was higher than that in the control group, and the difference was statistically significant(P<0.05). At discharge after the first treatment and at 6months after the first treatment, the scores of post-cancer fertility concerns in the intervention group were lower than those in the control group, and the scores of fertility preservation-related knowledge were higher than those in the control group,with statistically significant differences(all P<0.001). Conclusion: The decision-making assistance program for patients with lymphoma of childbearing age constructed in this study reduces the decision-making dilemma and post-cancer fertility concerns of patients, and improves their understanding of fertility preservation-related knowledge.更多还原