【摘要】 开发了一种新型牙本质小管封闭材料,其具有锌的抗菌性、相转变溶菌酶（PTL）的表面黏附性和中空介孔二氧化硅（HMSN）的可搭载药物特性.首先,利用硬模板法和选择性刻蚀法,以硅酸四乙酯为硅源制备了HMSN;通过HMSN表面负电荷的静电作用吸附Zn²⁺,制得Zn²⁺@HMSN;随后,使用PTL包覆Zn²⁺@HMSN,获得了具有抗菌性和黏附性的Zn²⁺/PTL@HMSN复合材料.Zn²⁺/PTL@HMSN不仅具有优异的生物相容性,可严密封闭牙本质小管,还具有良好的耐酸耐磨稳定性;并且Zn²⁺/PTL@HMSN可有效抑制变异链球菌的黏附,在治疗牙本质敏感方面具有良好的应用潜力.更多还原

【Abstract】 This study developed a novel dentinal tubule sealant material that combines the antibacterial properties of zinc,the surface adhesivity of phase-transitioned lysozyme（PTL）,and the drug-loading capabilities of hollow me soporous silica（HMSN）.Initially,HMSN were synthesized using the hard templating method and selective etching,with tetraethyl orthosilicate as the silica source.The negatively charged surfaces of HMSN adsorbed Zn²⁺ions through electrostatic attraction,forming Zn²⁺@HMSN.Subsequently,Zn²⁺@HMSN was encapsulated with PTL,resulting in Zn²⁺/PTL@HMSN composite material which exhibited antibacterial activity and enhanced adhesion.Zn²⁺/PTL@HMSN not only exhibited outstanding biocompatibility which could seal dentinal tubules effectively,but also demonstrated robust resistance to acid and wear.Zn²⁺/PTL@HMSN significantly inhibited the adhesion of streptococcus mutans,underscoring its great potential for treating dentinal hypersensitivity.更多还原