【摘要】 为了解决生物酶不稳定、易失活及纳米药物递送效率较低的问题,研究人员将纳米酶的高效稳定催化作用与微纳米马达的自主运动能力相结合,设计并制备了基于纳米酶的微纳米马达,用于在病变部位主动靶向递送药物并响应特定信号可控释放药物,在药物递送应用中表现出巨大的潜力.本文基于纳米酶马达“动-控-用”的发展思路,综合评述了代表性的构建微纳米马达的纳米酶,探讨了微纳米马达的运动调控策略,系统地梳理了基于纳米酶的微纳米马达在精准药物递送领域的前沿应用,并对该技术在实际应用中面临的挑战和未来发展进行了总结与展望.更多还原

【Abstract】 To solve the problems of instability, inactivation of natural enzymes and to tackle the limitations of low delivery efficiency, nanozyme-based micro/nanomotors have been designed and prepared. These motors, with the combination of the efficient and stable catalytic ability of nanozyme and the autonomous motion capability of micro/nanomotors, could achieve active targeted drug delivery at the diseased site and respond to specific signals for intelligent and controllable drug release, therefore exhibiting significant potential in smart drug delivery applications.Following the developing idea of “from motility, to controllability and applicability”, this paper provides a comprehensive review of various types of nanozymes, discusses the motion regulatory strategies of micro/nanomotors, systematically reviews the cutting-edge applications of nanozyme-based micro/nanomotors in precision drug delivery, and summarizes the challenges and future development prospects for this technology in practical application, wishing to provide fundamental guidance for the development of this field.更多还原