【摘要】 目的 了解上海市浦东新区动物源性食品中喹诺酮类兽药的污染状况，评估15岁以上居民的膳食暴露量及健康风险。方法 2021—2024年在上海市浦东新区36个街道（镇）内采集的272件动物源性食品，按照国家标准检测方法进行恩诺沙星等10种喹诺酮类药物的检测，结合已有的15岁以上上海市居民膳食消费量和体重数据，用点评估和Monte Carlo模拟概率评估相结合的方法对动物源性食品中的喹诺酮进行暴露风险评估。结果 2021—2024年在上海市浦东新区动物源性食品中喹诺酮类药物的总检出率为27.21%。鱼、虾、禽、蛋类中均为环丙沙星和恩诺沙星之和的检出率最高，分别是50.43%、14.29%、10.26%和3.41%，残留浓度最高的为鱼类中环丙沙星和恩诺沙星之和，中位数达到1.03μg/kg。通过Monte Carlo模拟计算风险商（hazard quotient,HQ）,4类食品中喹诺酮风险商（HQ）的中位数和P_97.5均远低于1。结论 浦东新区15岁以上居民动物源性食品中喹诺酮类兽药有一定量的检出和超标,但喹诺酮膳食暴露健康风险较低。更多还原

【Abstract】 Objective To investigate the contamination status of quinolone veterinary drugs in foods of animal origin within the Pudong New District of Shanghai and to assess the associated dietary exposure and health risks for the population over 15 years of age. Methods Between 2021 and 2024, a total of 272 samples of animal-derived foods were collected from 36 administrative sub-districts(towns) in the Pudong New District. The samples were analyzed for ten quinolone compounds, including enrofloxacin, following Chinese national standard analytical methods. A risk assessment of dietary exposure to quinolones was conducted by integrating point estimation with Monte Carlo probabilistic simulation, utilizing established data on dietary consumption and body weight for Shanghai residents aged 15 and above. Results The overall detection rate of quinolones in the sampled foods of animal origin was 27.21%. The highest detection rates were observed for the sum of ciprofloxacin and enrofloxacin in fish(50.43%), shrimp(14.29%), poultry(10.26%), and eggs(3.41%), respectively. The highest median residual concentration was also for the sum of ciprofloxacin and enrofloxacin in fish, reaching 1.03 μg/kg. The hazard quotients(HQs) derived from the Monte Carlo simulation revealed that both the median and the 97.5 th percentile HQs for quinolones across the four food categories were substantially lower than 1. Conclusion Although quantifiable levels and instances of non-compliance with maximum residue limits for quinolone veterinary drugs were identified in foods of animal origin in the Pudong New District, the health risk associated with dietary exposure for residents aged 15 and over is estimated to be low.更多还原