【摘要】 目的 探究超重/肥胖人群骨钙素(OCN)与内脏脂肪面积(VFA)的相关性。方法 分析2021年8月至2024年8月在西安交通大学第二附属医院健康管理部进行健康体检的297例超重/肥胖人群的资料。根据体脂分析测定的VFA值将研究对象分为超标组(VFA≥100 cm~2)与正常组(VFA<100 cm~2),比较两组的基线资料、糖代谢指标、脂代谢指标、OCN等各项指标的差异，经二元logistic回归分析影响超重/肥胖人群内脏脂肪沉积的独立危险因素。结果 根据VFA值结果，超标组共193例，占64.98%;正常组共104例，占35.02%。两组的性别、年龄和合并疾病差异无统计学意义(P>0.05),超标组的BMI值、FPG、HbA1c、TC、TG、LDL-C高于正常组；HDL-C、OCN值低于正常组(P<0.05)。二元logistic回归分析结果显示，BMI、FPG、HbA1c、TC、TG、LDL-C值均为影响超重/肥胖人群内脏脂肪沉积的独立危险因素，而HDL-C和OCN值是保护因素(P<0.05)。结论 超重/肥胖人群的内脏脂肪沉积与OCN含量密切相关，且受糖、脂代谢异常的影响，为预防和治疗肥胖相关疾病提供新的思路。更多还原

【Abstract】 Objective To explore the correlation between osteocalcin(OCN) and visceral fat area(VFA) in overweight/obese population. Methods The data of 297 overweight/obese people who underwent health examinations in Health Management Department of Second Affiliated Hospital of Xi′an Jiaotong University from August 2021 to August 2024 were analyzed.According to the VFA value measured by InBody, the subjects were divided into an excessive group(VFA ≥100 cm~2) and a normal group(VFA<100 cm~2).The baseline data, glucose metabolism indicators, lipid metabolism indicators and OCN were compared between the two groups.Binary logistic regression analysis was used to analyze the independent risk factors affecting visceral fat deposition in overweight/obese people. Results According to the VFA value, there were 193 cases(64.98%) in the excessive group and 104 cases(35.02%) in the normal group.There were no statistical differences in gender, age and comorbidities between the two groups(P>0.05).The BMI,FPG,HbA1c, TC, TG, and LDL-C in the excessive group were higher than those in the normal group, while the HDL-C and OCN were lower than those in the normal group(P<0.05).Binary logistic regression analysis revealed that BMI,FPG,HbA1c, TC, TG and LDL-C were independent risk factors for visceral fat deposition in overweight/obese people, while HDL-C and OCN were protective factors(P<0.05). Conclusion Visceral fat deposition in overweight/obese people is closely related to OCN content, and is affected by abnormal glucolipid metabolism, which provides new ideas for the prevention and treatment of obesity-related diseases.更多还原