【摘要】 目的 研究盐酸伏诺拉生联合阿莫西林治疗胃食管反流病伴幽门螺杆菌(helicobacter pylori,Hp)感染的临床价值。方法 纳入2021年1月—2022年5月在福建中医药大学附属福鼎医院接受治疗的112例胃食管反流病伴Hp感染患者进行研究，按照随机数表法分为对照组和研究组各56例。对照组给予常规治疗(泮托拉唑+阿莫西林+克拉霉素+铋钾胶囊)；研究组给予盐酸伏诺拉生联合阿莫西林治疗。对两组患者的症状改善情况、Hp根除率和治疗依从性进行比较。结果 研究组胃食管反流病量表、反流性疾病诊断问卷、反流症状指数评分量表评分低于对照组，差异有统计学意义(P<0.05)。两组意向性治疗分析、改良意向治疗分析、符合方案治疗分析的Hp根除率差异无统计学意义(P>0.05)。研究组胸痛、烧心、反酸、声嘶、反食缓解时间短于对照组，差异有统计学意义(P<0.05)。研究组治疗依从性高于对照组，差异有统计学意义(P<0.05)。结论 盐酸伏诺拉生联合阿莫西林治疗胃食管反流病伴Hp感染，能进一步减轻临床症状，并提高治疗依从性；但其Hp根除率与传统的四联方案较为接近。更多还原

【Abstract】 Objective To study the clinical value of voronoxan hydrochloride combined with amoxicillin in the treatment of gastroesophageal reflux disease with helicobacter pylori(HP) infection. Methods One hundred and twelve patients with gastroesophageal reflux disease and Hp infection who were treated in Fuding Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2021 to May 2022 were included in the study.They were divided into two groups according to the random number table. Fifty-six patients in the control group were given conventional treatment(pantoprazole+amoxicillin+clarithromycin+bismuth potassium capsules), while 56 patients in the study group were given voronorason hydrochloride combined with amoxicillin. The symptom improvement, Hp eradication rate, and treatment compliance of two groups of patients were compared separately.Results The scores of the gastroesophageal reflux disease scale, reflux disease diagnosis questionnaire, and reflux symptom index scoring scale in the research group were lower than those in the control group(P <0.05). There was no statistically significant difference in the Hp eradication rate between the two groups of intention to treat analysis, modified intention to treat analysis, and compliant treatment analysis(P>0.05). The relief time of chest pain, heartburn, acid reflux, hoarseness, and regurgitation in the research group was shorter than that in the control group(P<0.05). The treatment compliance of the research group was higher than that of the control group(P<0.05).Conclusion The combination of furosemide hydrochloride and amoxicillin in the treatment of gastroesophageal reflux disease with Hp infection can effectively alleviate clinical symptoms and improve treatment compliance, but its Hp eradication rate is relatively close to the traditional quadruple therapy.更多还原