【摘要】 目的:了解有关吡咯喹啉醌(PQQ)生物学功能的研究现状和热点。方法:检索Web of Science核心合集数据库,分析建库至2023年5月29日收录的有关PQQ生物学功能的研究文献,运用文献计量分析方法,采用Microsoft Excel 2019、VOSviewer和RStudio软件对有关PQQ生物学功能的论文的发文数量、被引情况、国家、作者、关键词进行分析。结果:共检索到1 548篇文献,由来自55个国家的4 252位作者发表,其中美国、日本、中国的发文量较高。与氧化应激损伤相关的动物实验是近期的研究热点。结论:近年对PQQ的研究关注逐渐增加,研究热点集中在动物实验及作用机制,开展多中心临床试验探索其医学应用潜力是未来发展方向。更多还原

【Abstract】 Objective:To investigate the current research status and hotspots of biological function of pyrroloquinoline quinone（PQQ）.Methods The Web of Science Core Collection database was retrieved to investigate the literature on biological function of PQQ from database establishment to May.29^th,2023.By using the bibliometric analysis method,Microsoft Excel 2019,VOSviewer and RStudio software were employed to analyze the publication volume,citation situation,countries,authors and keywords of the literature related to the biological function of PQQ.Results:A total of 1,548 literature were retrieved,published by 4,252 authors from 55 countries.Among them,the United States,Japan and China took the lead.Studies related to oxidative stress injury have emerged as a prominent research focus in recent years.Conclusion:There has been a gradual surge in research interest towards PQQ.The major areas of study have predominantly centered on animal experimentation and biological function.Exploring its potential medical applications through multi-center clinical trials represents a crucial avenue for future development.更多还原