【摘要】 目的 探讨青海特定地区藏族育龄妇女甲状腺功能和肝肾功能之间的相关性，为持续消除碘缺乏病危害提供依据。方法 在农业区、牧业区采集18～48岁藏族育龄妇女血清，农业区29人、牧业区40人，测定肝肾功能指标。用多因素线性回归分析甲状腺功能和肝肾功能之间的关系。结果 农业区、牧业区藏族育龄妇女肝功能中的ALT、AST、ALP、TBIL比较差异均无统计学意义（Z=-0.28、-0.41、-1.16、-0.66,P>0.05）,TP、ALB比较差异有统计学意义（t=-7.74、-5.89,P<0.05）,农业区、牧业区藏族育龄妇女CREA比较差异有统计学意义（Z=-2.22,P<0.05）,UREA比较差异无统计学意义（t=1.34,P>0.05）。多因素线性回归分析显示，甲状腺功能中的FT₃、TT₃是影响ALB和TP水平的主要影响因素（P<0.05）。结论 本次调查农、牧业区藏族育龄妇女的肝肾功能中TP、ALB、CREA差异明显，甲状腺功能指标中的FT₃、TT₃是影响肝功能中ALB和TP水平的主要影响因素。说明当地特殊膳食结构、生活习惯，以及碘营养状态、甲状腺功能和肝肾功能之间存在着复杂关系。更多还原

【Abstract】 Objective To explore the correlation between thyroid function and liver and kidney function among Tibetan women of childbearing age in specific areas of Qinghai Province, so as to provide a basis for the continuous elimination of the harm of iodine deficiency disorders.Methods Serum samples were collected from 18-48-year-old Tibetan women of childbearing age in agricultural and pastoral areas, with 29 from the agricultural area and 40 from the pastoral area.Liver and kidney function indicators were measured.The relationship between thyroid function and liver and kidney function was analyzed by multiple linear regression.Results There were no statistically significant differences in ALT,AST,ALP and TBIL（Z=-0.28,-0.41,-1.16,-0.66,P>0.05）,and statistically significant differences in TP and ALB（t=-7.74,-5.89,P<0.05）,there was statistical difference in CREA between agricultural area and pastoral area（Z=-2.22,P<0.05）,but there was no statistical difference in UREA（t=1.34,P>0.05）.Multivariate linear regression analysis showed that FT₃ and TT₃ in thyroid function were the main influencing factors of ALB and TP levels（P<0.05）.Conclusion The difference of TP,ALB and CREA in liver and kidney function of Tibetan women of childbearing age in agricultural and pastoral areas is obvious.ALB is a risk factor for thyroid nodule.FT₃ and TT₃ of thyroid function indexes are the main influencing factors of ALB and TP levels in liver function.The results show that there are complex relationships among the special dietary structure, living habits, iodine nutritional status, thyroid function and liver and kidney function.更多还原