【摘要】 食管癌是一种致死率高、侵袭性强、早期诊断率低的恶性肿瘤，研究其分子机制和潜在的治疗靶点至关重要。E-钙黏蛋白（E-cadherin）作为一种钙依赖性的细胞间黏附分子，在维持上皮细胞极性和组织结构的完整性方面发挥着至关重要的作用。在食管癌进程中，E-cadherin的缺失通常伴随着上皮-间质转化的启动，这一过程与食管癌的侵袭性和转移性有关。E-cadherin的下调通过破坏细胞间的黏附连接，促进癌细胞的脱落和侵入周围组织，从而加速肿瘤的浸润与转移。临床上，E-cadherin的表达水平被视为预测食管癌侵袭性和患者预后的潜在生物标志物，能够有效抑制肿瘤细胞迁移与侵袭。E-cadherin的缺失还与肿瘤细胞对化疗和靶向治疗的耐药性增加密切相关，提示调控E-cadherin的表达可能成为克服耐药性的一种有效手段。未来的研究应进一步探索E-cadherin在食管癌中的调控机制及其在临床治疗中的应用前景。本研究综述E-cadherin在食管癌中的作用及其相关研究进展，以期为食管癌的精准治疗提供新的理论依据和治疗策略。更多还原

【Abstract】 Esophageal cancer is a highly lethal malignancy characterized by strong invasiveness and low early detection rates. Studying its molecular mechanisms and potential therapeutic targets is of utmost importance. E-cadherin, a cal-cium-dependent cell adhesion molecule, plays a critical role in maintaining epithelial cell polarity and the integrity of tissue structure. In esophageal cancer, the loss of E-cadherin is often accompanied by the initiation of epitheli-al-mesenchymal transition(EMT), a process associated with the invasiveness and metastasis of the tumor. Down-regulation of E-cadherin disrupts intercellular adhesion junctions, promotes cancer cell detachment, and facilitates their invasion into surrounding tissues, thereby accelerating tumor infiltration and metastasis. Clinically, the expression level of E-cadherin serves as a potential biomarker for predicting tumor invasiveness and patient prognosis. Effective regulation of E-cadherin expression can inhibit tumor cell migration and invasion. Fur-thermore, the loss of E-cadherin is closely associated with increased tumor cell resistance to chemotherapy and targeted therapy, suggesting that modulating E-cadherin expression may be an effective strategy to overcome drug resistance. Future research should further explore the regulatory mechanisms of E-cadherin in esophageal cancer and its potential clinical applications, providing new theoretical foundations and therapeutic strategies for precision medicine in esophageal cancer treatment. This paper reviews the role of E-cadherin in esophageal cancer and its related research progress.更多还原