【摘要】 目的 以“下焦湿热”理论为指导，观察己椒苈黄汤治疗腰椎间盘突出症急性期(ALDH)的临床疗效。方法 选择腰椎间盘突出症急性期瘀水停滞、湿热互结证患者106例，按随机数表法分为治疗组与对照组，各53例。治疗组脱落5例，剔除3例；对照组脱落4例，剔除1例，最终纳入患者93例。治疗组45例予己椒苈黄汤+盐酸乙哌立松片模拟剂+塞来昔布胶囊模拟剂口服，对照组48例予己椒苈黄汤模拟剂+盐酸乙哌立松片+塞来昔布胶囊口服，2组均连续治疗2周，比较2组临床疗效结果，比较2组治疗前、治疗第1周、第2周、第4周随访时疼痛视觉模拟评分法(VAS)评分、日本骨科协会腰痛疾患疗效评定标准(JOA)评分、臀部及下肢功能障碍指数(ODI)、中医证候总积分、疼痛程度，记录2组治疗后不良反应发生情况。结果 治疗组临床疗效总有效率(82.22%，37/45)高于对照组(72.91%，35/48)(P<0.05)。2组治疗及随访时各个时间点VAS疼痛评分、JOA评分、ODI功能指数、中医证候总积分与治疗前比较，差异均具有统计学意义(P<0.05)。治疗第1周、第2周时，2组VAS疼痛评分、JOA评分、ODI功能指数、中医证候总积分差异无统计学意义(P>0.05)。第4周随访时，治疗组VAS疼痛评分、JOA评分、ODI功能指数、中医证候总积分低于对照组。2组不良反应发生情况比较，差异无统计学意义(P>0.05)。结论 己椒苈黄汤治疗腰椎间盘突出症急性期瘀水停滞、湿热互结证患者，能有效缓解腰腿痛症状，改善腰椎功能。更多还原

【Abstract】 Objective To observe the clinical efficacy of Ji Jiao Li Huang decoction in the treatment of acute stage of lumbar disc herniation(ALDH) under the guidance of the theory of dampness-heat in lower jiao. Methods 106 patients with acute stage of stagnation of static blood and water and intermin-gled dampness-heat in lumbar disc herniation were selected and divided into the treatment group and the control group according to random number table method, with 53 cases in each group. 5 cases fell out of the treatment group and 3 cases were excuded; 4 cases fell out of the control group and 1 case was excluded, and ultimately 93 patients were included. 45 patients in the treatment group were treated with Ji Jiao Li Huang decoction, a simulated version of Eperisone Hydrochloride Tablets, and a simulated version of Celecoxib Capsules orally, while 48 patients in the control group were treated with a simulated version of Ji Jiao Li Huang decoction, Eperisone Hydrochloride Tablets, and Celecoxib Capsules orally. Both groups received continuous treatment for two weeks. The clinical effi cacy of two groups was compared. Visual Analogue Scale(VAS) scores, Japanese Orthopaedic Association(JOA) scores, Oswestry Disability Index(ODI), total score of traditional Chinese medicine(TCM) syndromes, and pain severity between two groups before treatment, and during the first, the second and the fourth week follow-up were compared. The occurrence of adverse reactions after treatment in two groups was recorded. Results The total eff ective rate of clinical effi cacy in the treatment group(82.22%, 37/45) was higher than that in the control group(72.91%, 35/48)(P <0.05). There were statistically signifi cant diff erences in VAS score, JOA score, ODI and total TCM syndrome score at various time points during treatment and follow-up in two groups(P <0.05). There were no statistically significant diff erences in VAS score, JOA score, ODI and total TCM syndrome score between two groups during the first week and the second weeks of treatment(P >0.05). At the fourth week follow-up, the VAS score, JOA score, ODI, and total score of TCM syndrome in the treatment group were lower than those in the control group. There was no statistically signifi cant diff erence in the occurrence of adverse reactions between two groups(P >0.05). Conclusion Ji Jiao Li Huang decoction can eff ectively alleviate symptoms of lower back and leg pain and improve lumbar spine function in patients with acute stage of stagnation of static blood and water and intermin-gled dampness-heat in lumbar disc herniation.更多还原