【摘要】 目的 系统评价磁共振成像(MRI)苍白球T1WI高信号对急性胆红素脑病(ABE)诊断结果的真实性。方法 检索Pubmed、Web of science、中国知网、万方数据库,收集有关MRI苍白球高信号在ABE诊断方面的文献。由两名研究者按照纳入标准及排除标准筛选文献,按照QUADAS-2量表对纳入的病例对照研究和队列研究进行质量评价。应用Stata/MP18.0、Review Manager5.3进行数据分析。结果 共纳入15篇文献。Meta分析结果显示苍白球T1WI高信号诊断ABE的灵敏度为0.90(95%CI=0.81-0.95),特异度为0.87(95%CI=0.75-0.93),其组间差异均具有统计学意义(P<0.01);SROC曲线下面积(AUC)为0.95(95%CI 0.92～0.96),该结果稳定性较高,纳入文献未见明显发表偏倚。结论 苍白球T1WI高信号对ABE诊断的灵敏度、特异度均较高,提示MRI苍白球T1WI高信号可以作为诊断ABE的有效指征。更多还原

【Abstract】 Objective To systematically evaluate the diagnostic value of magnetic resonance imaging(MRI) T1WI high signal in the globus pallidus for acute bilirubin encephalopathy(ABE). Methods Literature related to MRI high signal in the globus pallidus in the diagnosis of ABE was retrieved from Pubmed, Web of science, CNKI,and Wanfang databases. Two researchers screened the literature according to the inclusion and exclusion criteria, and evaluated the quality of the included case-control studies and cohort studies using the QUADAS-2 scale. Stata/MP18.0, Review Manager5.3, and RStudio were used for data analysis. Results A total of 15 articles were included. Meta-analysis results showed that the sensitivity of T1WI high signal in the globus pallidus in diagnosing ABE was 0.90(95%CI=0.81-0.95),and the specificity was 0.87(95%CI=0.75-0.93), with statistically significant differences between groups(P<0.01); the area under the SROC curve(AUC) was 0.95(95%CI 0.92-0.96), and the result was highly stable, with no significant publication bias in the included literature. Conclusion The sensitivity and specificity of T1WI high signal in the globus pallidus in the diagnosis of ABE are both high,suggesting that MRI T1WI high signal in the globus pallidus can be used as an effective indicator for the diagnosis of ABE.更多还原