【摘要】 目的 探讨可溶性fms样酪氨酸激酶-1（sFlt-1）与胎盘生长因子（PlGF）比值（sFlt-1/PlGF）预测子痫前期孕妇发生维生素D缺乏的价值。方法 选取2023年1-11月在重庆市綦江区妇幼保健院进行产检并能完成随访的740例单胎妊娠子痫前期孕妇为研究对象，根据1,25-二羟维生素D₃[1,25-（OH）₂D₃]水平分为正常组（n=44）和缺乏组（n=696）。收集各组产前体重、身高、BMI、年龄、新生儿体重、教育水平、职业等信息，并于孕12～14周空腹6～8 h后抽取5 mL外周静脉血，检测外周血sFlt-1、PlGF、1,25-（OH）₂D₃水平，并评估sFlt-1/PlGF对子痫前期发生维生素D缺乏的预测价值。结果 两组患者的身高、年龄、BMI、教育水平和职业等一般情况比较，差异均无统计学意义（P>0.05）。两组产前体重、1,25-（OH）₂D₃水平、sFlt-1/PlGF和新生儿体重比较，差异均有统计学意义（P<0.05）。单因素分析结果显示，产前体重、sFlt-1/PlGF、新生儿体重为PE患者发生维生素D缺乏的危险因素；多因素分析结果显示，sFlt-1/PlGF和新生儿体重为预测PE患者发生维生素D缺乏的因素（P<0.05）;所有这些变量纳入建立列线图模型。受试者工作特征（ROC）曲线显示训练组与验证组的曲线下面积（AUC）分别为0.66（95%CI:0.56～0.77）和0.63（95%CI:0.49～0.76）。结论 在子痫前期孕妇中，sFlt-1/PlGF升高可能是预测维生素D缺乏的一个早期预警指标。更多还原

【Abstract】 Objective To explore the value of the ratio of soluble FmS-like tyrosine kinase-1（sFlt-1） to placental growth factor（PlGF） in predicting vitamin D deficiency in pregnant women with preeclampsia.Methods A total of 740 singleton pregnant women who underwent prenatal examination in Qijiang Health Center for Maternal and Child Care from January to November 2023 and were able to complete follow-up were selected as the research subjects.They were divided into the normal group（n=44） and the deficiency group（n=696） according to the vitamin D [1,25-（OH）₂D₃] level.Information such as age, BMI,pregnancy history, family history and medical history of each group was collected.5 mL of peripheral venous blood was drawn after fasting for 6-8 hours at 12-14 weeks of pregnancy to detect the levels of sFlt-1,PlGF and vitamin D in peripheral blood, and evaluated the predictive value of sFlt-1/PlGF for vitamin D deficiency in preeclampsia.Results There were no statistically significant differences in general conditions such as height, age, BMI,educational level and occupation between the two groups（P>0.05）.There were statistically significant differences in the prenatal weight, vitamin D level, sFlt-1/PlGF and neonatal birth weight between the two groups（P<0.05）.The results of univariate analysis showed that the prenatal weight, sFlt-1/PlGF,and neonatal birth weight were risk factors for vitamin D deficiency in patients with PE.The results of multivariate analysis showed that sFlt-1/PlGF and neonatal birth weight were factors for predicting vitamin D deficiency in patients with PE（P<0.05）.All these variables are used to establish the nomogram prediction model.The receiver operating characteristic（ROC） curve showed that area under the curve（AUC） of the training group and the validation group was 0.66（95%CI:0.56-0.77） and 0.63（95%CI:0.49-0.76）,respectively.Conclusion In pregnant women with preeclampsia, elevated sFlt-1/PlGF may be an early warning indicator for predicting vitamin D deficiency.更多还原