【摘要】 目的 探索压缩感知黄金角径向稀疏并行采样（compressed sensing golden-angle radial sparse parallel, CS-GRASP）序列的优化方案，评价优化后的序列在屏气不佳患者肝脏动态对比增强磁共振成像（dynamic contrast enhanced-magnetic resonance imaging, DCE-MRI）的应用价值。材料与方法 回顾性分析2021年3月至2023年10月在我院行肝脏DCE-MRI检查的46例屏气不佳患者，其中CS-GRASP序列未优化组21例，优化组25例。分别在平扫、动脉早期、动脉晚期于肝门静脉主干、左支及右支水平，测量肝脏及竖脊肌的信号强度（signal intensty, SI）、标准差（standard deviation, SD）及图像背景噪声标准差的平均值（SD噪声），计算两组肝脏CS-GRASP图像信噪比（signal-to-noise ratio, SNR）、对比噪声比（contrast-noise-ratio, CNR）、SI变异系数（coefficient of variation, CV），并对肝左、右叶图像噪声，条纹伪影的严重程度，图像质量和肝脏结构清晰度进行了主观评分。结果 在平扫、动脉早期、动脉晚期，CS-GRASP优化组中肝左、右叶图像SNR、CNR均高于未优化组，CV值均低于未优化组，两组间肝右叶动脉早期图像CNR差异无统计学意义（P>0.05），余参数差异均有统计学意义（P<0.05）。CS-GRASP优化组中肝左、右叶图像噪声、条纹伪影、图像清晰度和整体图像质量得分均高于未优化组，差异有统计学意义（P<0.05）。结论 CS-GRASP序列优化方案可提高屏气不佳患者肝脏DCE-MRI检查的图像质量，降低条纹伪影，是屏气不佳患者进行肝脏DCE-MRI检查一种较好的替代方案。更多还原

【Abstract】 Objective: To explore the optimized scanning scheme for compressed sensing golden-angle radial sparse parallel sequence(CS-GRASP) and evaluate the application value of the optimized sequence in liver dynamic contrast-enhanced MRI(DCE-MRI) for patients with poor breath-holding. Materials and Methods: This retrospective analysis was conducted on 46 patients with poor breath-holding capability who underwent dynamic contrast enhanced-magnetic resonance imaging of the liver at our hospital from March 2021 to October 2023, including 21 patients in the unoptimized CS-GRASP group and 25 patients in the optimized group. Signal intensity(SI) of the liver and erector spinae, standard deviation(SD), and the mean standard deviation of image background noise(SD noise) were measured at the levels of the main hepatic portal vein and its left and right branches during non-contrast, early arterial, and late arterial phases. The signal-to-noise ratio(SNR), contrast-noise ratio(CNR), and coefficient of variation(CV) of SI for liver CS-GRASP images of both groups were calculated. Subjective scoring was conducted for image noise, the severity of streak artifacts,image quality, and clarity of liver structures in the left and right liver lobes. Results: During plain scanning, arterial early phase, and arterial late phase, the SNR and CNR of images of the left and right lobes of the liver in the CS-GRASP optimized group was higher than those in the unoptimized group, and the CV values were lower than that of the unoptimized group; the difference in CNR of the arterial early phase of the right lobe of the liver was not statistically significant between the two groups(P > 0.05), while the difference of the rest of the parameters were statistically significant(P < 0.05). In the CS-GRASP optimized group, scores for image noise and streak artifacts of the left and right liver lobes, scores for image clarity, and overall image quality were higher than those in the non-optimized group, with statistically significant differences(P < 0.05). Conclusions: The optimized CS-GRASP sequence can improve image quality and reduce streak artifacts, making it a better alternative for patients with poor breath-holding during liver contrast-enhanced MRI.更多还原