【摘要】 目的 在拮抗剂方案超促排卵并鲜胚移植周期助孕患者中，探索妊娠结局的独立影响因素，以提高鲜胚移植周期临床妊娠率。方法 回顾性分析2018年1月至2022年5月在滨州医学院附属医院生殖中心行体外受精-胚胎移植(in vitro fertilization/intracytoplasmic sperm injection and embryo transfer, IVF/ICSI-ET)共750周期的患者资料，按照是否临床妊娠分为临床妊娠组(337例)和非临床妊娠组(413例),统计分析两组患者的基本资料、促排卵参数及实验室数据并回归分析临床妊娠的独立影响因素。结果 两组患者年龄、不孕类型、基础卵泡刺激素、抗缪勒管激素、促性腺激素应用总量及天数、子宫内膜厚度、获卵数、2PN数、可利用胚胎数、优质胚胎数组间比较存在显著性差异(P<0.05);年龄、获卵数及优质胚胎数是影响此方案鲜胚移植周期临床妊娠结局的独立影响因素；8<获卵数≤11、优质胚胎数≥2个的患者选择鲜胚移植可获得较高的临床妊娠率(P<0.05)。结论 年龄、获卵数及优质胚胎数会影响拮抗剂方案鲜胚移植周期的临床妊娠结局，8<获卵数≤11,形成2个及以上优质胚胎的患者可优先选择鲜胚移植周期助孕。更多还原

【Abstract】 Objective To explore the independent influencing factors on pregnancy outcomes in patients undergoing superovulation with fresh embryo transfer cycle assisted conception on antagonist regimen in order to improve the clinical pregnancy rate on fresh embryo transfer cycle on this regimen.Methods Retrospective analysis was performed on patient data of a total of 750 cycles of in vitro fertilization/intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET)performed in the Reproductive Center of Binzhou Medical University Hospital from January 2018 to May 2022. The patients were divided into the clinical pregnancy group(337 cases)and the non-clinical pregnancy group(413 cases)according to whether they were clinically pregnant or not, and the basic data, ovulation parameters and laboratory data of the two groups were statistically analyzed and regressed to analyze the independent influencing factors of clinical pregnancy.Results There were differences in age, infertility type, basic follicle stimulating hormone, anti-Müllerian hormone, total number of gonadotropin applications and days, endometrial thickness, number of eggs obtained, number of 2PN, number of available embryos, and number of high-quality embryos between the two groups(P<0.05); age, number of eggs obtained, and number of high-quality embryos were independent factors affecting clinical pregnancy outcomes in fresh embryo transfer cycles of this program; patients with 8<number of eggs obtained≤11 and the number of high-quality embryos≥2 could achieve a higher clinical pregnancy rate by choosing the fresh embryo transfer cycle for assisted pregnancy.Conclusion Age, number of eggs obtained and number of high-quality embryos will affect the clinical pregnancy outcome of the fresh embryo transfer cycle in the antagonist regimen. Patients with 8<number of eggs obtained≤11 and the number of high-quality embryos≥2 can give priority to fresh embryo transplantation cycle for assisted pregnancy.更多还原