【摘要】 为提高无花果叶中补骨脂素的提取率，在考察酸性离子液体浸泡时间、液料比、碳酸氢钠和氯化钠用量等10个单因素试验基础上，通过Plackett-Burman试验筛选显著性影响因素，利用Box-Behnken响应面法优化提取工艺，采用超声辅助的酸性离子液体泡腾法实现补骨脂素的高效提取。结果表明：酸性离子液体浸泡时间、液料比、碳酸氢钠质量和提取超声温度是影响补骨脂素提取率的主要因素；响应面法优化的最佳提取工艺参数为酸性离子液体浸泡时间8.25 h、液料比11∶1(mL/g)、碳酸氢钠用量0.758 g、超声温度35℃，在此条件下得到补骨脂素提取率为12.03096 mg/g。研究为无花果叶中补骨脂素的开发利用提供技术支持。更多还原

【Abstract】 To improve the extraction rate of psoralen from fig leaves,ten single-factor experiments(including acidic ionic liquid immersion time,liquid-to-material ratio,sodium bicarbonate dosage,and sodium chloride dosage) were conducted.Significant influencing factors were screened via Plackett-Burman design,followed by optimization using Box-Behnken response surface methodology. Ultrasound-assisted acidic ionic liquid effervescence achieved efficient psoralen extraction. Results showed that acidic ionic liquid immersion time,liquid-to-material ratio,sodium bicarbonate mass,and ultrasonic temperature were key factors.Optimal conditions were:immersion time 8.25 h,liquid to material ratio 11∶1(mL/g),sodium bicarbonate 0.758 g,and ultrasound temperature 35 ℃,yielding a psoralen extraction rate of 12.03096 mg/g.This research provides technical support for utilizing psoralen from fig leaves.更多还原