【摘要】 目的:观察芪脊舒僵方治疗僵直少动型帕金森病脾肾阳虚证患者的临床疗效。方法:64例僵直少动型帕金森病脾肾阳虚证患者随机分为对照组和治疗组,每组32例。对照组采用多巴丝肼片口服治疗,治疗组在对照组治疗基础上给予芪脊舒僵方口服,两组均连续治疗12周。治疗12周后评价两组患者临床疗效,治疗前及治疗4、8、12周后评价两组患者帕金森病统一评分量表(UPDRS)评分、改良的霍思-雅尔(H-Y)分级评分、中医证候评分。结果:对照组总有效率为43.75%(14/32),治疗组总有效率为87.50%(28/32),治疗组显著高于对照组(P<0.05)。治疗12周后,治疗组H-Y分级较治疗前显著改善(P<0.01),且优于同期对照组(P<0.01)。治疗组治疗4、8、12周后UPDRSⅠ、UPDRSⅡ及治疗8、12周后UPDRSⅢ评分均显著低于同期对照组(P<0.01)。治疗组治疗后畏寒怕冷、自汗、头晕、肢体麻木、疲乏无力、少气懒言、身体疼痛、腰膝酸软、食量、食冷不适中医证候评分均较治疗前显著改善(P<0.05,P<0.01),且肢体麻木、疲乏无力、少气懒言、腰膝酸软、食量、食冷不适中医证候评分显著优于对照组(P<0.01)。结论:芪脊舒僵方能很好地改善僵直少动型帕金森病脾肾阳虚证患者症状,且安全有效。更多还原

【Abstract】 Objective: To observe the clinical efficacy of Qiji Shujiang Formula in the treatment of Parkinson disease(PD) patients with rigidity and bradykinesia in the spleen-kidney yang deficiency syndrome. Methods: Sixty-four PD patients with rigidity and bradykinesia and spleen-kidney yang deficiency syndrome were randomly divided into a control group and a treatment group, with 32 cases in each group. The control group was treated with oral administration of Madopar, while the treatment group was given Qiji Shujiang Formula on the basis of the control group’s treatment. Both groups were treated for 12 consecutive weeks.The clinical efficacy was evaluated at 12 weeks of treatment. Unified PD rating scale(UPDRS) score, modified Hoehn-Yahr(H-Y) staging score, and traditional Chinese medicine syndrome score were evaluated before treatment and at 4, 8, and 12 weeks of treatment. Results: The total effective rate of the control group was 43.75%(14/32), while that of the treatment group was 87.50%(28/32), which was significantly higher than that of the control group(P<0.05). After 12 weeks of treatment, the H-Y staging score of the treatment group was significantly improved compared with that before treatment(P<0.01), and was better than that of the control group at the same time(P<0.01). The UPDRS Ⅰ, UPDRS Ⅱ scores of the treatment group at 4, 8, and 12 weeks of treatment and the UPDRS Ⅲ scores at 8 and 12 weeks of treatment were significantly lower than those of the control group at the same time(P<0.01). After treatment, the traditional Chinese medicine syndrome scores of aversion to cold, spontaneous sweating,dizziness, limb numbness, fatigue, shortness of breath, body pain, soreness and weakness of the waist and knees, appetite, and discomfort after eating cold food in the treatment group were significantly improved compared with those before treatment(P<0.05,P<0.01), and the scores of limb numbness, fatigue, shortness of breath, soreness and weakness of the waist and knees, appetite,and discomfort after eating cold food were significantly better than those of the control group(P<0.01). Conclusion: Qiji Shujiang Formula can effectively improve the symptoms of PD patients with rigidity and bradykinesia and spleen-kidney yang deficiency syndrome with safety and effectiveness.更多还原