【摘要】 目的：探讨血清镁浓度与多囊卵巢综合征（PCOS）患者血脂异常之间的相关性分析及其潜在机制。方法：925例临床数据根据血清镁浓度分为低镁组473例（<0.87 mmol/L）和高镁组452例（≥0.87 mmol/L），比较两组患者间糖脂代谢、肝肾功差异，并与血脂谱进行相关性分析；基于毒性与基因比较数据库（CTD）、GeneCards、OMIM数据库挖掘镁与PCOS血脂异常相关基因，构建蛋白互作（PPI）网络图，并基于Metascape数据库进行KEGG和GO富集分析。结果：临床数据分析显示与高镁组比较，低镁组甘油三酯（TG）、总胆固醇（TC）、载脂蛋白A(APOA)、载脂蛋白B(APOB)、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）水平明显升高，差异有统计学意义（P<0.05）。相关分析显示，血清镁与APOA、TC、HDL、LDL、APOB、TG(r或rs分别为-0.265、-0.223、-0.195、-0.191、-0.173、-0.077)呈明显负相关。基因挖掘结果显示，镁与PCOS血脂异常之间共有36个共同基因；KEGG和GO功能富集分析结果显示，镁可能作用于胰岛素（INS）、胰岛素受体（INSR）、白介素1β(IL1β)、纤溶酶原激活物抑制剂1(SERPINE1)等脂质合成和分解代谢靶点，影响HIF-1、AMPK和PI3K-Akt信号通路以及胰岛素抵抗、脂质和动脉粥样硬化等发生发展。结论：血清镁水平与PCOS血脂异常之间可能是负相关，可能通过调控HIF-1、AMPK和PI3K-Akt信号通路，参与胰岛素抵抗、脂质与动脉粥样硬化等的发生。更多还原

【Abstract】 Objective: To investigate the correlation analysis between serum magnesium concentration and dyslipidemia in patients with polycystic ovary syndrome(PCOS) and its potential mechanisms. Methods: A total of 925 cases clinical data were divided into low magnesium group with 473 cases(<0.87 mmol/L) and high magnesium group with 452 cases(≥0.87 mmol/L)according to serum magnesium concentration, comparing the differences in glucose and lipid metabolism, liver and kidney function between the two groups and correlating with lipid profile; The genes of mining magnesium and PCOS dyslipidemia related were identified based on toxicity and gene comparison database(CTD), GeneCards, OMIM database protein interaction(PPI) network maps were constructed, and KEGG and GO enrichment analyses were performed based on Metascape database. Results: Clinical data analysis showed significantly higher levels of triglycerides(TG), total cholesterol(TC), apolipoprotein A(APOA), apolipoprotein B(APOB), high-density lipoprotein(HDL), and low-density lipoprotein(LDL) in the low-magnesium group compared with the highmagnesium group, with statistically significant differences(P<0.05). Correlation analysis showed a significant negative correlation between magnesium and APOA, TC, HDL, LDL, APOB, and TG(r or rs were-0.265,-0.223,-0.195,-0.191,-0.173,-0.077,respectively). Gene mining results showed that there were 36 common genes between magnesium and PCOS dyslipidemia; KEGG and GO functional enrichment analysis showed that magnesium may act on lipid synthesis and catabolic targets such as insulin(INS),insulin receptor(INSR), interleukin 1β(IL1β), and inhibitor of fibrinogen activator 1(SERPINE1), affecting HIF-1, AMPK, and PI3K-Akt signaling pathways as well as the development of insulin resistance, lipids, and atherosclerosis. Conclusion: There may be a negative correlation between serum magnesium level and dyslipidemia of PCOS, which may be involved in the occurrence of insulin resistance, lipid and atherosclerosis by regulating HIF-1, AMPK and PI3K-Akt signaling pathways.更多还原