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输血后超溶血综合征研究进展
Research progress of hyperhemolytic syndrome after transfusion
【摘要】 输血后溶血性输血反应包括急性溶血性输血反应和迟发性溶血性输血反应,但是临床出现输血后Hb水平不但未升高,反而低于输血前,在排除创伤、手术等出血和大量输液稀释等因素外,即受血者红细胞也发生溶血的现象,即超溶血综合征。由于超溶血综合征发生机理目前尚不完全清楚,国内文献报道极少,临床认识不足,易于漏诊误诊。本文综合文献归纳和总结了7种可能的发生机理或机制,并对超溶血综合征的概念、临床特征、发生机理和临床治疗进行综述。
【Abstract】 Hemolytic transfusion reactions after transfusion include acute hemolytic transfusion reaction and delayed hemolytic transfusion reaction. However, clinically, it is observed that after transfusion, the hemoglobin(Hb) level not only fails to increase but is actually lower than before transfusion. Excluding factors such as bleeding from trauma or surgery and dilution from large volume infusions, this indicates that the recipient′s red blood cells are undergoing hemolysis, a phenomenon known as hyperhemolysis syndrome. The mechanism of hyperhemolytic syndrome is not completely clear, there are few reports in domestic literature, and clinical understanding is insufficient, which is easy to miss and misdiagnosis. This paper summarizes seven possible mechanisms of hyperhemolytic syndrome and reviews the concept, clinical features, pathogenesis and clinical treatment of hyperhemolytic syndrome.
【Key words】 hyperhemolytic syndrome; bystander hemolysis; blood transfusion; acute hemolytic transfusion reaction; delayed hemolytic transfusion reaction;
- 【文献出处】 中国输血杂志 ,Chinese Journal of Blood Transfusion , 编辑部邮箱 ,2025年02期
- 【分类号】R457.1
- 【下载频次】79