【摘要】 目的 探讨血小板及其相关指标[血小板计数（PLT）、纤维蛋白原（FBG）、D-二聚体（D-D）]在结直肠癌（CRC）诊断及疗效预测中的应用价值。方法 选取60例CRC患者作为试验组，60例健康者作为对照组，采用电阻抗技术检测两组受试者PLT水平，采用免疫比浊法检测FBG、D-D水平。试验组患者新辅助化疗结束后第4周评估疗效，根据评估结果分为治疗有效和治疗无效。比较两组受试者及不同疗效CRC患者的PLT、D-D、FBG水平。采用受试者工作特征（ROC）曲线及曲线下面积（AUC）分析PLT、D-D、FBG单独及联合检测对CRC的诊断价值及对治疗无效的预测价值。结果 试验组患者PLT、D-D、FBG水平均明显高于对照组，差异均有统计学意义（P﹤0.01）。治疗无效患者PLT、D-D、FBG水平均明显高于治疗有效患者，差异均有统计学意义（P﹤0.01）。PLT、D-D、FBG联合检测诊断CRC和预测治疗无效的AUC均最大，高于各指标单独检测。结论 PLT、D-D、FBG在CRC患者中水平较高，与CRC的发生及发展有关，三项指标联合检测对CRC的诊断价值及对治疗无效的预测价值最高。更多还原

【Abstract】 Objective To explore the application value of platelet and its related indexes [platelet count(PLT), fibrinogen(FBG), D-dimer(D-D)] in diagnosis and curative effect prediction of colorectal cancer. Method A total of 60 CRC patients were selected as the experimental group and 60 healthy subjects as the control group. The PLT levels in the two groups were detected by electrical impedance technology, the FBG and D-D levels were detected by immunoturbidimetry.The efficacy of the experimental group was evaluated 4 weeks after the end of neoadjuvant chemotherapy. According to the evaluation results, the patients were divided into effective treatment and ineffective treatment. The PLT, D-D and FBG levels of two groups and CRC patients with different curative effects were compared. Receiver operating characteristic(ROC) curve and area under the curve(AUC) were used to analyze the diagnostic value of PLT, D-D and FBG single and combined detection for CRC and their prediction value for ineffective treatment. Result The levels of PLT, D-D and FBG in experimental group were significantly higher than those in control group, and the differences were statistically significant(P<0.01). The levels of PLT, D-D and FBG in patients with ineffective treatment were significantly higher than those in patients with effective treatment, and the differences were statistically significant(P<0.01). The combined detection of PLT, D-D and FBG had the largest AUC in the diagnosis of CRC and the prediction of ineffective treatment,which were higher than the single detection of each index. Conclusion The levels of PLT, D-D and FBG are high in CRC patients, which are related to the occurrence and development of CRC. The combined detection of these three indexes has the highest value in the diagnosis of CRC and the prediction of ineffective treatment.更多还原