【摘要】 目的：观察铁皮石斛治疗鼻咽癌（NPC）患者放射性口腔黏膜炎（RIOM）的临床疗效。方法：2020年7月—2022年5月浙江省肿瘤医院头颈放疗科门诊及病房收治的60例NPC患者，按照随机数字表法分为治疗组（n=30）和对照组（n=30）。对照组使用复方维生素B₁₂溶液含漱口腔，治疗组在对照组的基础上予铁皮石斛以代茶饮的形式口服，2组均连续治疗4周，比较2组治疗后的临床疗效、治疗前后的中医证候评分以及血常规、肝肾功能等指标。结果：经过4周治疗后，治疗组有效率（26.7%）高于对照组（3.3%），且治疗组加重率（50%）低于对照组（93.3%），差异均具有统计学意义。对照组的中医证候评分较治疗前显著增加，以口干口渴、灼热不适、口疮、红肿疼痛、大便秘结症状为著，而五心烦热、失眠盗汗症状加重不明显。而治疗组仅有口干口渴症状较治疗前加重，其余症状较前均无明显变化。结论：铁皮石斛治疗NPC患者RIOM的疗效显著，能够有效缓解放疗期间RIOM的一系列阴虚火旺症状并延缓其加剧，较好地改善NPC患者的生活质量，有利于患者的恢复并改善其预后。更多还原

【Abstract】 Objective:To observe the clinical efficacy of Dendrobium officinale in the treatment of radiation oral mucositis (RIOM) in patients with nasopharyngeal carcinoma (NPC).Methods:A total of 60 patients with NPC who were admitted to the outpatient department and ward of the Department of Head and Neck Radiotherapy of Zhejiang Cancer Hospital from July 2020 to May 2022 were randomly divided into a treatment group (n=30) and a control group (n=30) according to the random number table method.The control group used compound vitamin B12 solution to rinse the mouth,and the treatment group was given Dendrobium officinale in the form of tea on the basis of the control group.Both groups were treated for 4 consecutive weeks.The clinical efficacy after treatment,the TCM syndrome scores before and after treatment,and the blood routine,liver and kidney function and other indicators were compared between the two groups.Results:After 4 weeks of treatment,the effective rate (26.7%) of the treatment group was higher than that of the control group (3.3%),and the aggravation rate (50%) of the treatment group was lower than that of the control group (93.3%),and the differences were statistically significant.The TCM syndrome scores of the control group increased significantly compared with those before treatment,with symptoms of dry mouth and thirst,burning discomfort,mouth sores,redness,swelling and pain,and constipation as the most prominent ones,while the symptoms of five-heart heat,insomnia and night sweats did not increase significantly.In the treatment group,only the symptoms of dry mouth and thirst increased compared with those before treatment,and the other symptoms did not change significantly compared with those before treatment.Conclusion:Dendrobium candidum has a significant effect in the treatment of radiation oral mucositis in patients with nasopharyngeal carcinoma.It can effectively relieve a series of yin deficiency and hyperactivity of fire symptoms of RIOM during radiotherapy and delay its aggravation,improve the quality of life of patients with nasopharyngeal carcinoma,and is conducive to the recovery of patients and improve their prognosis.更多还原