【摘要】 骨纤维异常增殖症（Fibrous dysplasia,FD）是一种由异常的纤维-骨结缔组织取代正常的骨组织所导致的良性骨组织病变，常发生在颅面部，恶变是其最具破坏性的进展之一。该病知之甚少的危险因素和发病机制，潜在的暴发性临床表现和晚期扩散使之成为临床治疗的难点。本文就颅面骨纤维异常增殖症继发恶性肿瘤的发病机制、临床表现、治疗及预后等方面进行综述，为临床诊疗及相关研究提供参考。更多还原

【Abstract】 Fibrous dysplasia(FD) is a benign disease caused by the replacement of normal bone tissue by abnormal fibrous-bone connective tissue, often occurring in the craniofacial area, with malignancy being one of the most devastating progressions. Its poorly understood risk factors and pathogenesis, potentially fulminant clinical manifestations, and advanced spread make craniofacial fibrous dysplasia malignant a challenge. In this paper, the pathogenesis, clinical manifestations, treatments, and prognosis of craniofacial fibrous dysplasia malignant were reviewed to provide a reference for its clinical diagnosis, treatment, and further research.更多还原